The role of adrenaline as a modulator of cardiac performance in three Notothenioid fishes
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The role of adrenaline as a modulator of cardiac performance in three Notothenioid fishes. / Skov, Peter Vilhelm; Bushnell, P.; Tirsgaard, Bjørn; Steffensen, John Fleng.
In: Comparative Biochemistry and Physiology A, Vol. 150, No. 3, Supplement, A5.3, 2008, p. S97-S98.Research output: Contribution to journal › Conference abstract in journal › Research
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T1 - The role of adrenaline as a modulator of cardiac performance in three Notothenioid fishes
AU - Skov, Peter Vilhelm
AU - Bushnell, P.
AU - Tirsgaard, Bjørn
AU - Steffensen, John Fleng
N1 - Udgivelsesdato: July 2008 Volumne: 150
PY - 2008
Y1 - 2008
N2 - The present work was performed to test the hypothesis that Antarctic teleosts rely mostly on cholinergic inhibition to modulate cardiac performance. Isometric muscle preparations were used to examine the inotropic and chronotropic properties of the ventricle and atrium in three Antarctic teleosts. The importance of adrenaline as a neurotransmitter was evaluated through a series of dose-response experiments in conjunction with increasing pacing frequencies, to establish whether adrenaline modulated force of contraction and the maximum frequency with which tissues could contract. Only in Chaenocephalus aceratus did increasing adrenaline have an effect on chronotropic properties, but in no tissues did increasing adrenaline enable tissues to operate at higher pacing frequencies. Atrial tissues could consistently be paced at higher frequencies than their ventricular counterparts. There was a three-fold difference in force of contraction at the lowest pacing frequency and tonic adrenaline level between species. Increasing adrenaline enhanced peak tension for all ventricular tissues, yet the response was highly species specific, increasing force of contraction two to four-fold. Only in one species did adrenaline appear to enhance force of contraction for atrial muscle. The study finds that adrenaline modulates ventricular inotropic properties in all species. For Notothenia coriiceps the regulation of power production purely by adrenergic stimulation appeared most beneficial, while for N. microlepidota and C. aceratus a combination of pacing frequency and adrenaline yielded the greatest response. The results are discussed with respect to the life-style, temperature and cardiac morphometry of the species investigated.
AB - The present work was performed to test the hypothesis that Antarctic teleosts rely mostly on cholinergic inhibition to modulate cardiac performance. Isometric muscle preparations were used to examine the inotropic and chronotropic properties of the ventricle and atrium in three Antarctic teleosts. The importance of adrenaline as a neurotransmitter was evaluated through a series of dose-response experiments in conjunction with increasing pacing frequencies, to establish whether adrenaline modulated force of contraction and the maximum frequency with which tissues could contract. Only in Chaenocephalus aceratus did increasing adrenaline have an effect on chronotropic properties, but in no tissues did increasing adrenaline enable tissues to operate at higher pacing frequencies. Atrial tissues could consistently be paced at higher frequencies than their ventricular counterparts. There was a three-fold difference in force of contraction at the lowest pacing frequency and tonic adrenaline level between species. Increasing adrenaline enhanced peak tension for all ventricular tissues, yet the response was highly species specific, increasing force of contraction two to four-fold. Only in one species did adrenaline appear to enhance force of contraction for atrial muscle. The study finds that adrenaline modulates ventricular inotropic properties in all species. For Notothenia coriiceps the regulation of power production purely by adrenergic stimulation appeared most beneficial, while for N. microlepidota and C. aceratus a combination of pacing frequency and adrenaline yielded the greatest response. The results are discussed with respect to the life-style, temperature and cardiac morphometry of the species investigated.
U2 - 10.1016/j.cbpa.2008.04.193
DO - 10.1016/j.cbpa.2008.04.193
M3 - Conference abstract in journal
VL - 150
SP - S97-S98
JO - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
SN - 1095-6433
IS - 3, Supplement
M1 - A5.3
Y2 - 6 July 2008 through 10 July 2010
ER -
ID: 22019870