A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome

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A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome. / Li, Shenghui; Guo, Ruochun; Zhang, Yue; Li, Peng; Chen, Fang; Wang, Xifan; Li, Jing; Jie, Zhuye; Lv, Qingbo; Jin, Hao; Wang, Guangyang; Yan, Qiulong.

In: iScience, Vol. 25, No. 6, 104418, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, S, Guo, R, Zhang, Y, Li, P, Chen, F, Wang, X, Li, J, Jie, Z, Lv, Q, Jin, H, Wang, G & Yan, Q 2022, 'A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome', iScience, vol. 25, no. 6, 104418. https://doi.org/10.1016/j.isci.2022.104418

APA

Li, S., Guo, R., Zhang, Y., Li, P., Chen, F., Wang, X., Li, J., Jie, Z., Lv, Q., Jin, H., Wang, G., & Yan, Q. (2022). A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome. iScience, 25(6), [104418]. https://doi.org/10.1016/j.isci.2022.104418

Vancouver

Li S, Guo R, Zhang Y, Li P, Chen F, Wang X et al. A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome. iScience. 2022;25(6). 104418. https://doi.org/10.1016/j.isci.2022.104418

Author

Li, Shenghui ; Guo, Ruochun ; Zhang, Yue ; Li, Peng ; Chen, Fang ; Wang, Xifan ; Li, Jing ; Jie, Zhuye ; Lv, Qingbo ; Jin, Hao ; Wang, Guangyang ; Yan, Qiulong. / A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome. In: iScience. 2022 ; Vol. 25, No. 6.

Bibtex

@article{7bfd8844e2db4e90805019c40ece14a5,

title = "A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome",

abstract = "The human oral cavity is a hotspot of numerous, mostly unexplored, viruses that are important for maintaining oral health and microbiome homeostasis. Here, we analyzed 2,792 publicly available oral metagenomes and proposed the Oral Virus Database (OVD) comprising 48,425 nonredundant viral genomes (≥5 kbp). The OVD catalog substantially expanded the known phylogenetic diversity and host specificity of oral viruses, allowing for enhanced delineation of some underrepresented groups such as the predicted Saccharibacteria phages and jumbo viruses. Comparisons of the viral diversity and abundance of different oral cavity habitats suggested strong niche specialization of viromes within individuals. The virome variations in relation to host geography and properties were further uncovered, especially the age-dependent viral compositional signatures in saliva. Overall, the viral genome catalog describes the architecture and variability of the human oral virome, while offering new resources and insights for current and future studies.",

author = "Shenghui Li and Ruochun Guo and Yue Zhang and Peng Li and Fang Chen and Xifan Wang and Jing Li and Zhuye Jie and Qingbo Lv and Hao Jin and Guangyang Wang and Qiulong Yan",

note = "{\textcopyright} 2022 The Author(s).",

year = "2022",

doi = "10.1016/j.isci.2022.104418",

language = "English",

volume = "25",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - A catalog of 48,425 nonredundant viruses from oral metagenomes expands the horizon of the human oral virome

AU - Li, Shenghui

AU - Guo, Ruochun

AU - Zhang, Yue

AU - Li, Peng

AU - Chen, Fang

AU - Wang, Xifan

AU - Li, Jing

AU - Jie, Zhuye

AU - Lv, Qingbo

AU - Jin, Hao

AU - Wang, Guangyang

AU - Yan, Qiulong

PY - 2022

Y1 - 2022

N2 - The human oral cavity is a hotspot of numerous, mostly unexplored, viruses that are important for maintaining oral health and microbiome homeostasis. Here, we analyzed 2,792 publicly available oral metagenomes and proposed the Oral Virus Database (OVD) comprising 48,425 nonredundant viral genomes (≥5 kbp). The OVD catalog substantially expanded the known phylogenetic diversity and host specificity of oral viruses, allowing for enhanced delineation of some underrepresented groups such as the predicted Saccharibacteria phages and jumbo viruses. Comparisons of the viral diversity and abundance of different oral cavity habitats suggested strong niche specialization of viromes within individuals. The virome variations in relation to host geography and properties were further uncovered, especially the age-dependent viral compositional signatures in saliva. Overall, the viral genome catalog describes the architecture and variability of the human oral virome, while offering new resources and insights for current and future studies.

AB - The human oral cavity is a hotspot of numerous, mostly unexplored, viruses that are important for maintaining oral health and microbiome homeostasis. Here, we analyzed 2,792 publicly available oral metagenomes and proposed the Oral Virus Database (OVD) comprising 48,425 nonredundant viral genomes (≥5 kbp). The OVD catalog substantially expanded the known phylogenetic diversity and host specificity of oral viruses, allowing for enhanced delineation of some underrepresented groups such as the predicted Saccharibacteria phages and jumbo viruses. Comparisons of the viral diversity and abundance of different oral cavity habitats suggested strong niche specialization of viromes within individuals. The virome variations in relation to host geography and properties were further uncovered, especially the age-dependent viral compositional signatures in saliva. Overall, the viral genome catalog describes the architecture and variability of the human oral virome, while offering new resources and insights for current and future studies.

U2 - 10.1016/j.isci.2022.104418

DO - 10.1016/j.isci.2022.104418

M3 - Journal article

C2 - 35663034

VL - 25

JO - iScience

JF - iScience

SN - 2589-0042

IS - 6

M1 - 104418

ER -

ID: 312498380

Department of Biology