A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients
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A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients. / Stein, Wilfred D; Litman, Thomas; Fojo, Tito; Bates, Susan E.
In: Biochimica et Biophysica Acta - General Subjects, Vol. 1770, No. 6, 2007, p. 857-871.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients
AU - Stein, Wilfred D
AU - Litman, Thomas
AU - Fojo, Tito
AU - Bates, Susan E
PY - 2007
Y1 - 2007
N2 - A published microarray gene expression database containing data on 174 tumor samples from ten tissues was mined, enabling the identification of classes of genes whose expression correlates significantly with the intractability, or tractability, to therapy of tumors derived from such tissues. As a measure of tractability, the 5-year survival of patients presenting with distant (metastatic) tumors was used. Genes that encode proteins related to cell adhesion, and enzymes involved in metabolic oxidation or reduction, were upregulated in intractable cancers. Genes that encode proteins implicated in the control of DNA transcription were downregulated in the intractable cancers. We describe hypotheses with regard to cell functions that may help in designing new therapeutic modalities, aimed at improving survival of cancer patients.
AB - A published microarray gene expression database containing data on 174 tumor samples from ten tissues was mined, enabling the identification of classes of genes whose expression correlates significantly with the intractability, or tractability, to therapy of tumors derived from such tissues. As a measure of tractability, the 5-year survival of patients presenting with distant (metastatic) tumors was used. Genes that encode proteins related to cell adhesion, and enzymes involved in metabolic oxidation or reduction, were upregulated in intractable cancers. Genes that encode proteins implicated in the control of DNA transcription were downregulated in the intractable cancers. We describe hypotheses with regard to cell functions that may help in designing new therapeutic modalities, aimed at improving survival of cancer patients.
KW - Databases, Genetic
KW - Disease-Free Survival
KW - Female
KW - Gene Expression Regulation, Neoplastic
KW - Genes, Neoplasm
KW - Humans
KW - Male
KW - Models, Biological
KW - Neoplasm Metastasis
KW - Neoplasm Proteins
KW - Neoplasms
KW - Retrospective Studies
KW - Time Factors
U2 - 10.1016/j.bbagen.2006.12.013
DO - 10.1016/j.bbagen.2006.12.013
M3 - Journal article
C2 - 17398010
VL - 1770
SP - 857
EP - 871
JO - B B A - General Subjects
JF - B B A - General Subjects
SN - 0304-4165
IS - 6
ER -
ID: 119646244