A population of stem cells with strong regenerative potential discovered in deer antlers

Research output: Contribution to journal › Journal article › Research › peer-review

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A population of stem cells with strong regenerative potential discovered in deer antlers. / Qin, Tao; Zhang, Guokun; Zheng, Yi; Li, Shengyou; Yuan, Yuan; Li, Qingjie; Hu, Mingliang; Si, Huazhe; Wei, Guanning; Gao, Xueli; Cui, Xinxin; Xia, Bing; Ren, Jing; Wang, Kun; Ba, Hengxing; Liu, Zhen; Heller, Rasmus; Li, Zhipeng; Wang, Wen; Huang, Jinghui; Li, Chunyi; Qiu, Qiang.

In: Science (New York, N.Y.), Vol. 379, No. 6634, 2023, p. 840-847.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Qin, T, Zhang, G, Zheng, Y, Li, S, Yuan, Y, Li, Q, Hu, M, Si, H, Wei, G, Gao, X, Cui, X, Xia, B, Ren, J, Wang, K, Ba, H, Liu, Z, Heller, R, Li, Z, Wang, W, Huang, J, Li, C & Qiu, Q 2023, 'A population of stem cells with strong regenerative potential discovered in deer antlers', Science (New York, N.Y.), vol. 379, no. 6634, pp. 840-847. https://doi.org/10.1126/science.add0488

APA

Qin, T., Zhang, G., Zheng, Y., Li, S., Yuan, Y., Li, Q., Hu, M., Si, H., Wei, G., Gao, X., Cui, X., Xia, B., Ren, J., Wang, K., Ba, H., Liu, Z., Heller, R., Li, Z., Wang, W., ... Qiu, Q. (2023). A population of stem cells with strong regenerative potential discovered in deer antlers. Science (New York, N.Y.), 379(6634), 840-847. https://doi.org/10.1126/science.add0488

Vancouver

Qin T, Zhang G, Zheng Y, Li S, Yuan Y, Li Q et al. A population of stem cells with strong regenerative potential discovered in deer antlers. Science (New York, N.Y.). 2023;379(6634):840-847. https://doi.org/10.1126/science.add0488

Author

Qin, Tao ; Zhang, Guokun ; Zheng, Yi ; Li, Shengyou ; Yuan, Yuan ; Li, Qingjie ; Hu, Mingliang ; Si, Huazhe ; Wei, Guanning ; Gao, Xueli ; Cui, Xinxin ; Xia, Bing ; Ren, Jing ; Wang, Kun ; Ba, Hengxing ; Liu, Zhen ; Heller, Rasmus ; Li, Zhipeng ; Wang, Wen ; Huang, Jinghui ; Li, Chunyi ; Qiu, Qiang. / A population of stem cells with strong regenerative potential discovered in deer antlers. In: Science (New York, N.Y.). 2023 ; Vol. 379, No. 6634. pp. 840-847.

Bibtex

@article{2d5bebc2f77b420f9adbc119f7cf0960,
title = "A population of stem cells with strong regenerative potential discovered in deer antlers",
abstract = "The annual regrowth of deer antlers provides a valuable model for studying organ regeneration in mammals. We describe a single-cell atlas of antler regrowth. The earliest-stage antler initiators were mesenchymal cells that express the paired related homeobox 1 gene (PRRX1+ mesenchymal cells). We also identified a population of {"}antler blastema progenitor cells{"} (ABPCs) that developed from the PRRX1+ mesenchymal cells and directed the antler regeneration process. Cross-species comparisons identified ABPCs in several mammalian blastema. In vivo and in vitro ABPCs displayed strong self-renewal ability and could generate osteochondral lineage cells. Last, we observed a spatially well-structured pattern of cellular and gene expression in antler growth center during the peak growth stage, revealing the cellular mechanisms involved in rapid antler elongation.",
author = "Tao Qin and Guokun Zhang and Yi Zheng and Shengyou Li and Yuan Yuan and Qingjie Li and Mingliang Hu and Huazhe Si and Guanning Wei and Xueli Gao and Xinxin Cui and Bing Xia and Jing Ren and Kun Wang and Hengxing Ba and Zhen Liu and Rasmus Heller and Zhipeng Li and Wen Wang and Jinghui Huang and Chunyi Li and Qiang Qiu",
year = "2023",
doi = "10.1126/science.add0488",
language = "English",
volume = "379",
pages = "840--847",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6634",

}

RIS

TY - JOUR

T1 - A population of stem cells with strong regenerative potential discovered in deer antlers

AU - Qin, Tao

AU - Zhang, Guokun

AU - Zheng, Yi

AU - Li, Shengyou

AU - Yuan, Yuan

AU - Li, Qingjie

AU - Hu, Mingliang

AU - Si, Huazhe

AU - Wei, Guanning

AU - Gao, Xueli

AU - Cui, Xinxin

AU - Xia, Bing

AU - Ren, Jing

AU - Wang, Kun

AU - Ba, Hengxing

AU - Liu, Zhen

AU - Heller, Rasmus

AU - Li, Zhipeng

AU - Wang, Wen

AU - Huang, Jinghui

AU - Li, Chunyi

AU - Qiu, Qiang

PY - 2023

Y1 - 2023

N2 - The annual regrowth of deer antlers provides a valuable model for studying organ regeneration in mammals. We describe a single-cell atlas of antler regrowth. The earliest-stage antler initiators were mesenchymal cells that express the paired related homeobox 1 gene (PRRX1+ mesenchymal cells). We also identified a population of "antler blastema progenitor cells" (ABPCs) that developed from the PRRX1+ mesenchymal cells and directed the antler regeneration process. Cross-species comparisons identified ABPCs in several mammalian blastema. In vivo and in vitro ABPCs displayed strong self-renewal ability and could generate osteochondral lineage cells. Last, we observed a spatially well-structured pattern of cellular and gene expression in antler growth center during the peak growth stage, revealing the cellular mechanisms involved in rapid antler elongation.

AB - The annual regrowth of deer antlers provides a valuable model for studying organ regeneration in mammals. We describe a single-cell atlas of antler regrowth. The earliest-stage antler initiators were mesenchymal cells that express the paired related homeobox 1 gene (PRRX1+ mesenchymal cells). We also identified a population of "antler blastema progenitor cells" (ABPCs) that developed from the PRRX1+ mesenchymal cells and directed the antler regeneration process. Cross-species comparisons identified ABPCs in several mammalian blastema. In vivo and in vitro ABPCs displayed strong self-renewal ability and could generate osteochondral lineage cells. Last, we observed a spatially well-structured pattern of cellular and gene expression in antler growth center during the peak growth stage, revealing the cellular mechanisms involved in rapid antler elongation.

U2 - 10.1126/science.add0488

DO - 10.1126/science.add0488

M3 - Journal article

C2 - 36821675

AN - SCOPUS:85148679947

VL - 379

SP - 840

EP - 847

JO - Science

JF - Science

SN - 0036-8075

IS - 6634

ER -

ID: 338525003