A transomic cohort as a reference point for promoting a healthy human gut microbiome
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A transomic cohort as a reference point for promoting a healthy human gut microbiome. / Jie, Zhuye; Liang, Suisha; Ding, Qiuxia; Li, Fei; Tang, Shanmei; Wang, Dan; Lin, Yuxiang; Chen, Peishan; Cai, Kaiye; Qiu, Xuemei; Li, Qiang; Liao, Yunli; Zhou, Dongsheng; Lian, Heng; Zuo, Yong; Chen, Xiaomin; Rao, Weiqiao; Ren, Yan; Wang, Yuan; Zi, Jin; Wang, Rong; Zhou, Hongcheng; Lu, Haorong; Wang, Xiaohan; Zhang, Wei; Zhang, Tao; Xiao, Liang; Zong, Yang; Liu, Weibin; Yang, Huanming; Wang, Jian; Hou, Yong; Liu, Xiao; Kristiansen, Karsten; Zhong, Huanzi; Jia, Huijue; Xu, Xun.
In: Medicine in Microecology, Vol. 8, 100039, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A transomic cohort as a reference point for promoting a healthy human gut microbiome
AU - Jie, Zhuye
AU - Liang, Suisha
AU - Ding, Qiuxia
AU - Li, Fei
AU - Tang, Shanmei
AU - Wang, Dan
AU - Lin, Yuxiang
AU - Chen, Peishan
AU - Cai, Kaiye
AU - Qiu, Xuemei
AU - Li, Qiang
AU - Liao, Yunli
AU - Zhou, Dongsheng
AU - Lian, Heng
AU - Zuo, Yong
AU - Chen, Xiaomin
AU - Rao, Weiqiao
AU - Ren, Yan
AU - Wang, Yuan
AU - Zi, Jin
AU - Wang, Rong
AU - Zhou, Hongcheng
AU - Lu, Haorong
AU - Wang, Xiaohan
AU - Zhang, Wei
AU - Zhang, Tao
AU - Xiao, Liang
AU - Zong, Yang
AU - Liu, Weibin
AU - Yang, Huanming
AU - Wang, Jian
AU - Hou, Yong
AU - Liu, Xiao
AU - Kristiansen, Karsten
AU - Zhong, Huanzi
AU - Jia, Huijue
AU - Xu, Xun
N1 - Publisher Copyright: © 2021
PY - 2021
Y1 - 2021
N2 - More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics data need to be measured to better understand the gut microbiome. Here, we present a cohort including 2183 adults with high-depth metagenomic shotgun sequencing data for the fecal microbiome and other omics data. In this multiomic cohort, we observe a number of vitamins, hormones, amino acids, and trace elements that correlated with the gut microbiome. Many of the associations are validated in an additional cohort consisting of 1404 individuals. Our comprehensive data are poised to provide advice to future populations and mechanistic study designs to better understand and manage our gut microbiome.
AB - More than a decade of gut microbiome studies have a common goal of improving human health. However, while most of the disease studies have focused on the elderly or the middle-aged, a reference cohort for the gut microbiome in young individuals has been lacking. It is also not clear what other omics data need to be measured to better understand the gut microbiome. Here, we present a cohort including 2183 adults with high-depth metagenomic shotgun sequencing data for the fecal microbiome and other omics data. In this multiomic cohort, we observe a number of vitamins, hormones, amino acids, and trace elements that correlated with the gut microbiome. Many of the associations are validated in an additional cohort consisting of 1404 individuals. Our comprehensive data are poised to provide advice to future populations and mechanistic study designs to better understand and manage our gut microbiome.
U2 - 10.1016/j.medmic.2021.100039
DO - 10.1016/j.medmic.2021.100039
M3 - Journal article
AN - SCOPUS:85112437571
VL - 8
JO - Medicine in Microecology
JF - Medicine in Microecology
SN - 2590-0978
M1 - 100039
ER -
ID: 278037115