A unified architecture of transcriptional regulatory elements

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A unified architecture of transcriptional regulatory elements. / Andersson, Robin; Sandelin, Albin Gustav; Danko, Charles G.

In: Trends in Genetics, Vol. 31, No. 8, 08.2015, p. 426-433.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Andersson, R, Sandelin, AG & Danko, CG 2015, 'A unified architecture of transcriptional regulatory elements', Trends in Genetics, vol. 31, no. 8, pp. 426-433. https://doi.org/10.1016/j.tig.2015.05.007

APA

Andersson, R., Sandelin, A. G., & Danko, C. G. (2015). A unified architecture of transcriptional regulatory elements. Trends in Genetics, 31(8), 426-433. https://doi.org/10.1016/j.tig.2015.05.007

Vancouver

Andersson R, Sandelin AG, Danko CG. A unified architecture of transcriptional regulatory elements. Trends in Genetics. 2015 Aug;31(8):426-433. https://doi.org/10.1016/j.tig.2015.05.007

Author

Andersson, Robin ; Sandelin, Albin Gustav ; Danko, Charles G. / A unified architecture of transcriptional regulatory elements. In: Trends in Genetics. 2015 ; Vol. 31, No. 8. pp. 426-433.

Bibtex

@article{d79dac54251a4fb6a3cd725e20944131,

title = "A unified architecture of transcriptional regulatory elements",

abstract = "Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.",

author = "Robin Andersson and Sandelin, {Albin Gustav} and Danko, {Charles G.}",

year = "2015",

month = aug,

doi = "10.1016/j.tig.2015.05.007",

language = "English",

volume = "31",

pages = "426--433",

journal = "Trends in Genetics",

issn = "0168-9525",

publisher = "Elsevier Ltd. * Trends Journals",

number = "8",

}

RIS

TY - JOUR

T1 - A unified architecture of transcriptional regulatory elements

AU - Andersson, Robin

AU - Sandelin, Albin Gustav

AU - Danko, Charles G.

PY - 2015/8

Y1 - 2015/8

N2 - Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.

AB - Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.

U2 - 10.1016/j.tig.2015.05.007

DO - 10.1016/j.tig.2015.05.007

M3 - Journal article

C2 - 26073855

VL - 31

SP - 426

EP - 433

JO - Trends in Genetics

JF - Trends in Genetics

SN - 0168-9525

IS - 8

ER -

ID: 141985309

Department of Biology