TY - JOUR

T1 - Amino acids and the changing face of the α-cell

AU - Hamilton, Alexander

AU - Eliasson, Lena

AU - Knudsen, Jakob G.

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - Glucagon has long been defined by its glucogenic action and as a result α-cells have been characterised based largely on their interaction with glucose. Recent findings have challenged this preconception, bringing to the fore the significant role glucagon plays in amino acid breakdown and underlining the importance of amino acids in glucagon secretion. The challenge that remains is defining the mechanism that underlie these effects - understanding which amino acids are most important, how they act on the α-cell and how their actions integrate with other fuels such as glucose and fatty acids. This review will describe the current relationship between amino acids and glucagon and how we can use this knowledge to redefine the α-cell.

AB - Glucagon has long been defined by its glucogenic action and as a result α-cells have been characterised based largely on their interaction with glucose. Recent findings have challenged this preconception, bringing to the fore the significant role glucagon plays in amino acid breakdown and underlining the importance of amino acids in glucagon secretion. The challenge that remains is defining the mechanism that underlie these effects - understanding which amino acids are most important, how they act on the α-cell and how their actions integrate with other fuels such as glucose and fatty acids. This review will describe the current relationship between amino acids and glucagon and how we can use this knowledge to redefine the α-cell.

KW - Alpha cell

KW - Amino acids

KW - Glucagon

KW - Liver-α cell axis

KW - Type 2 diabetes

U2 - 10.1016/j.peptides.2023.171039

DO - 10.1016/j.peptides.2023.171039

M3 - Journal article

C2 - 37295651

AN - SCOPUS:85161702045

VL - 166

JO - Peptides

JF - Peptides

SN - 0196-9781

M1 - 171039

ER -