Applying Undertaker to quality assessment

Research output: Contribution to journalJournal articleResearchpeer-review

  • John G. Archie
  • Martin Paluszewski
  • Kevin Karplus
Our group tested three quality assessment functions in CASP8: a function which used only distance constraints derived from alignments (SAM-T08-MQAO), a function which added other single-model terms to the distance constraints (SAM-T08-MQAU), and a function which used both single-model and consensus terms (SAM-T08-MQAC). We analyzed the functions both for ranking models for a single target and for producing an accurate estimate of GDT_TS. Our functions were optimized for the ranking problem, so are perhaps more appropriate for metaserver applications than for providing trustworthiness estimates for single models. On the CASP8 test, the functions with more terms performed better. The MQAC consensus method was substantially better than either single-model function, and the MQAU function was substantially better than the MQAO function that used only constraints from alignments. Proteins 2009. © 2009 Wiley-Liss, Inc.
Original languageEnglish
JournalProteins - Structure Function and Bioinformatics
Volume77
Issue numberS9
Pages (from-to)191-195
ISSN0887-3585
DOIs
Publication statusPublished - 2009

Bibliographical note

Keywords
Undertaker • quality assessment • CASP • metaserver

ID: 17558355