Bioactive compounds from aquatic and terrestrial sources
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Bioactive compounds from aquatic and terrestrial sources. / Rinehart, Kenneth L.; Holt, Tom G.; Fregeau, Nancy L.; Keifer, Paul A.; Robert Wilson, George; Thomas, J. Perun; Sakai, Ryuichi; Thompson, Anthony G.; Stroh, Justin G.; Shield, Lois S.; Seigler, David S.; Li, Li H.; Martin, David G.; Grimmelikhuijzen, Cornelis J.P.; Gäde, Gerd.
In: Journal of Natural Products, Vol. 53, No. 4, 1990, p. 771-792.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bioactive compounds from aquatic and terrestrial sources
AU - Rinehart, Kenneth L.
AU - Holt, Tom G.
AU - Fregeau, Nancy L.
AU - Keifer, Paul A.
AU - Robert Wilson, George
AU - Thomas, J. Perun
AU - Sakai, Ryuichi
AU - Thompson, Anthony G.
AU - Stroh, Justin G.
AU - Shield, Lois S.
AU - Seigler, David S.
AU - Li, Li H.
AU - Martin, David G.
AU - Grimmelikhuijzen, Cornelis J.P.
AU - Gäde, Gerd
PY - 1990
Y1 - 1990
N2 - The world of nature provides a never-ending set of fascinating problems for the chemist. Many of the most intriguing problems, however, concern compounds available in only truly minute quantities. One solution is to focus on bioassay-guided separations. In so doing one can isolate compounds with novel structures or unsuspected activities from almost any phylum, including tunicates, sponges, insects, or even the much-studied terrestrial plants, as exemplified in several recent studies in our laboratory involving activities ranging from antiviral and antimicrobial activity to cytotoxicity and immunomodulation Moreover, newer spectroscopic techniques, especially fest atom bombardment mass spectrometry and tandem mass spectrometry, enhance one's ability to study compounds present in minute quantities, including those of importance to the host organism, such as neuropeptides in insects or marine invertebrates.
AB - The world of nature provides a never-ending set of fascinating problems for the chemist. Many of the most intriguing problems, however, concern compounds available in only truly minute quantities. One solution is to focus on bioassay-guided separations. In so doing one can isolate compounds with novel structures or unsuspected activities from almost any phylum, including tunicates, sponges, insects, or even the much-studied terrestrial plants, as exemplified in several recent studies in our laboratory involving activities ranging from antiviral and antimicrobial activity to cytotoxicity and immunomodulation Moreover, newer spectroscopic techniques, especially fest atom bombardment mass spectrometry and tandem mass spectrometry, enhance one's ability to study compounds present in minute quantities, including those of importance to the host organism, such as neuropeptides in insects or marine invertebrates.
UR - http://www.scopus.com/inward/record.url?scp=0025131974&partnerID=8YFLogxK
U2 - 10.1021/np50070a001
DO - 10.1021/np50070a001
M3 - Journal article
C2 - 2095373
AN - SCOPUS:0025131974
VL - 53
SP - 771
EP - 792
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 4
ER -
ID: 370740634