Comparative genomics reveals the hybrid origin of a macaque group
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Comparative genomics reveals the hybrid origin of a macaque group. / Zhang, Bao Lin; Chen, Wu; Wang, Zefu; Pang, Wei; Luo, Meng Ting; Wang, Sheng; Shao, Yong; He, Wen Qiang; Deng, Yuan; Zhou, Long; Chen, Jiawei; Yang, Min Min; Wu, Yajiang; Wang, Lu; Fernández-Bellon, Hugo; Molloy, Sandra; Meunier, Hélène; Wanert, Fanélie; Kuderna, Lukas; Marques-Bonet, Tomas; Roos, Christian; Qi, Xiao Guang; Li, Ming; Liu, Zhijin; Schierup, Mikkel Heide; Cooper, David N.; Liu, Jianquan; Zheng, Yong Tang; Zhang, Guojie; Wu, Dong Dong.
In: Science Advances, Vol. 9, No. 22, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparative genomics reveals the hybrid origin of a macaque group
AU - Zhang, Bao Lin
AU - Chen, Wu
AU - Wang, Zefu
AU - Pang, Wei
AU - Luo, Meng Ting
AU - Wang, Sheng
AU - Shao, Yong
AU - He, Wen Qiang
AU - Deng, Yuan
AU - Zhou, Long
AU - Chen, Jiawei
AU - Yang, Min Min
AU - Wu, Yajiang
AU - Wang, Lu
AU - Fernández-Bellon, Hugo
AU - Molloy, Sandra
AU - Meunier, Hélène
AU - Wanert, Fanélie
AU - Kuderna, Lukas
AU - Marques-Bonet, Tomas
AU - Roos, Christian
AU - Qi, Xiao Guang
AU - Li, Ming
AU - Liu, Zhijin
AU - Schierup, Mikkel Heide
AU - Cooper, David N.
AU - Liu, Jianquan
AU - Zheng, Yong Tang
AU - Zhang, Guojie
AU - Wu, Dong Dong
PY - 2023
Y1 - 2023
N2 - Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that the fascicularis group originated from an ancient hybridization between the sinica and silenus groups ~3.45 to 3.56 million years ago. The X chromosomes and low-recombination regions exhibited equal contributions from each parental lineage, suggesting that they were less affected by subsequent backcrossing and hence could have played an important role in maintaining hybrid integrity. We identified many reproduction-associated genes that could have contributed to the development of the mixed sexual phenotypes characteristic of the fascicularis group. The phylogeny within the silenus group was also resolved, and functional experimentation confirmed that all extant Western silenus species are susceptible to HIV-1 infection. Our study provides novel insights into macaque evolution and reveals a hybrid speciation event that has occurred only very rarely in primates.
AB - Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that the fascicularis group originated from an ancient hybridization between the sinica and silenus groups ~3.45 to 3.56 million years ago. The X chromosomes and low-recombination regions exhibited equal contributions from each parental lineage, suggesting that they were less affected by subsequent backcrossing and hence could have played an important role in maintaining hybrid integrity. We identified many reproduction-associated genes that could have contributed to the development of the mixed sexual phenotypes characteristic of the fascicularis group. The phylogeny within the silenus group was also resolved, and functional experimentation confirmed that all extant Western silenus species are susceptible to HIV-1 infection. Our study provides novel insights into macaque evolution and reveals a hybrid speciation event that has occurred only very rarely in primates.
U2 - 10.1126/sciadv.add3580
DO - 10.1126/sciadv.add3580
M3 - Journal article
C2 - 37262187
AN - SCOPUS:85160969104
VL - 9
JO - Science advances
JF - Science advances
SN - 2375-2548
IS - 22
ER -
ID: 356425837