Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection
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Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection. / Salgado-Albarrán, Marisol; Navarro-Delgado, Erick I.; Del Moral-Morales, Aylin; Alcaraz, Nicolas; Baumbach, Jan; González-Barrios, Rodrigo; Soto-Reyes, Ernesto.
In: n p j Systems Biology and Applications, Vol. 7, 21, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Comparative transcriptome analysis reveals key epigenetic targets in SARS-CoV-2 infection
AU - Salgado-Albarrán, Marisol
AU - Navarro-Delgado, Erick I.
AU - Del Moral-Morales, Aylin
AU - Alcaraz, Nicolas
AU - Baumbach, Jan
AU - González-Barrios, Rodrigo
AU - Soto-Reyes, Ernesto
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in SARS-CoV-2 infection in order to propose drug-based therapeutic options. Transcriptional changes due to epigenetic regulation are key host cell responses to viral infection and have been studied in SARS-CoV and MERS-CoV; however, such changes are not fully described for SARS-CoV-2. In this study, we analyzed multiple transcriptomes obtained from cell lines infected with MERS-CoV, SARS-CoV, and SARS-CoV-2, and from COVID-19 patient-derived samples. Using integrative analyses of gene co-expression networks and de-novo pathway enrichment, we characterize different gene modules and protein pathways enriched with Transcription Factors or Epifactors relevant for SARS-CoV-2 infection. We identified EP300, MOV10, RELA, and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that has therapeutic potential. Our results show that targeting the epigenetic machinery could be a feasible alternative to treat COVID-19.
AB - COVID-19 is an infection caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2), which has caused a global outbreak. Current research efforts are focused on the understanding of the molecular mechanisms involved in SARS-CoV-2 infection in order to propose drug-based therapeutic options. Transcriptional changes due to epigenetic regulation are key host cell responses to viral infection and have been studied in SARS-CoV and MERS-CoV; however, such changes are not fully described for SARS-CoV-2. In this study, we analyzed multiple transcriptomes obtained from cell lines infected with MERS-CoV, SARS-CoV, and SARS-CoV-2, and from COVID-19 patient-derived samples. Using integrative analyses of gene co-expression networks and de-novo pathway enrichment, we characterize different gene modules and protein pathways enriched with Transcription Factors or Epifactors relevant for SARS-CoV-2 infection. We identified EP300, MOV10, RELA, and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that has therapeutic potential. Our results show that targeting the epigenetic machinery could be a feasible alternative to treat COVID-19.
U2 - 10.1038/s41540-021-00181-x
DO - 10.1038/s41540-021-00181-x
M3 - Journal article
C2 - 34031419
AN - SCOPUS:85106759169
VL - 7
JO - n p j Systems Biology and Applications
JF - n p j Systems Biology and Applications
SN - 2056-7189
M1 - 21
ER -
ID: 272015669