Excitatory action of the native neuropeptide antho-rfamide on muscles in the pennatulid Renilla köllikeri
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Excitatory action of the native neuropeptide antho-rfamide on muscles in the pennatulid Renilla köllikeri. / Anctil, M; Grimmelikhuijzen, C J.
In: Advances in General and Cellular Pharmacology, Vol. 20, No. 3, 01.01.1989, p. 381-4.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Excitatory action of the native neuropeptide antho-rfamide on muscles in the pennatulid Renilla köllikeri
AU - Anctil, M
AU - Grimmelikhuijzen, C J
PY - 1989/1/1
Y1 - 1989/1/1
N2 - 1. Antho-RFamide (pGlu-Gly-Arg-Phe-amide), a neuropeptide recently isolated from the sea pansy Renilla köllikeri induced sustained (tonic) contractions in the rachis and peduncle of the colony, and in the individual autozooid polyps. 2. The threshold concentration for this effect was 5 nM in summer colonies and 1 microM in autumn or winter colonies. 3. The peptide-induced tonic contractions were unaffected in sodium-free sea water. There was a 30% reduction of the contraction amplitude in sea water lacking calcium. 4. Peptides related to Antho-RFamide and other peptides were also examined for activity on rachidial muscles. Only peptides containing the carboxyterminal sequence Arg-Phe-amide were active. 5. It is concluded that Antho-RFamide acts on Renilla muscles via a specific receptor and that it is a candidate for neurotransmitter or modulator in this pennatulid.
AB - 1. Antho-RFamide (pGlu-Gly-Arg-Phe-amide), a neuropeptide recently isolated from the sea pansy Renilla köllikeri induced sustained (tonic) contractions in the rachis and peduncle of the colony, and in the individual autozooid polyps. 2. The threshold concentration for this effect was 5 nM in summer colonies and 1 microM in autumn or winter colonies. 3. The peptide-induced tonic contractions were unaffected in sodium-free sea water. There was a 30% reduction of the contraction amplitude in sea water lacking calcium. 4. Peptides related to Antho-RFamide and other peptides were also examined for activity on rachidial muscles. Only peptides containing the carboxyterminal sequence Arg-Phe-amide were active. 5. It is concluded that Antho-RFamide acts on Renilla muscles via a specific receptor and that it is a candidate for neurotransmitter or modulator in this pennatulid.
KW - Animals
KW - Calcium
KW - Cnidaria
KW - Electric Stimulation
KW - Muscle Contraction
KW - Muscles
KW - Neuropeptides
KW - Pyrrolidonecarboxylic Acid
M3 - Journal article
C2 - 2568307
VL - 20
SP - 381
EP - 384
JO - Advances in General and Cellular Pharmacology
JF - Advances in General and Cellular Pharmacology
SN - 0146-3810
IS - 3
ER -
ID: 33514357