From embryonic stem cells to testicular germ cell cancer-- should we be concerned?
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From embryonic stem cells to testicular germ cell cancer-- should we be concerned? / Almstrup, Kristian; Sonne, Si Brask; Hoei-Hansen, Christina E; Ottesen, Anne Marie; Nielsen, John E; Skakkebaek, Niels E; Leffers, Henrik; Rajpert-De Meyts, Ewa.
In: International Journal of Andrology, Vol. 29, No. 1, 2006, p. 211-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - From embryonic stem cells to testicular germ cell cancer-- should we be concerned?
AU - Almstrup, Kristian
AU - Sonne, Si Brask
AU - Hoei-Hansen, Christina E
AU - Ottesen, Anne Marie
AU - Nielsen, John E
AU - Skakkebaek, Niels E
AU - Leffers, Henrik
AU - Rajpert-De Meyts, Ewa
N1 - Keywords: Carcinoma in Situ; Germinoma; Humans; Male; Neoplasms, Germ Cell and Embryonal; Seminoma; Stem Cells; Testicular Neoplasms
PY - 2006
Y1 - 2006
N2 - Since the discovery of testicular carcinoma in situ (CIS) -- the precursor cell for the vast majority of germ cell tumours -- it has been proposed that CIS cells could be derived from transformed primordial germ cells or gonocytes. Here, we review recent discoveries not only substantiating that initial hypothesis but also indicating that CIS cells have a striking phenotypic similarity to embryonic stem cells (ESC). Many cancers have been proposed to originate from tissue-specific stem cells [so-called 'cancer stem cells' (CSC)] and we argue that CIS may be a very good example of a CSC, but with exceptional features due to the retention of embryonic pluripotency. In addition, considering the fact that pre-invasive CIS cells are transformed from early fetal cells, possibly due to environmentally induced alterations of the niche, we discuss potential risks linked to the uncontrolled therapeutic use of ESC.
AB - Since the discovery of testicular carcinoma in situ (CIS) -- the precursor cell for the vast majority of germ cell tumours -- it has been proposed that CIS cells could be derived from transformed primordial germ cells or gonocytes. Here, we review recent discoveries not only substantiating that initial hypothesis but also indicating that CIS cells have a striking phenotypic similarity to embryonic stem cells (ESC). Many cancers have been proposed to originate from tissue-specific stem cells [so-called 'cancer stem cells' (CSC)] and we argue that CIS may be a very good example of a CSC, but with exceptional features due to the retention of embryonic pluripotency. In addition, considering the fact that pre-invasive CIS cells are transformed from early fetal cells, possibly due to environmentally induced alterations of the niche, we discuss potential risks linked to the uncontrolled therapeutic use of ESC.
U2 - 10.1111/j.1365-2605.2005.00643.x
DO - 10.1111/j.1365-2605.2005.00643.x
M3 - Journal article
C2 - 16466542
VL - 29
SP - 211
EP - 218
JO - International Journal of Andrology
JF - International Journal of Andrology
SN - 0105-6263
IS - 1
ER -
ID: 18150877