TY - JOUR

T1 - Genomic organization of a receptor from sea anemones, structurally and evolutionary related to glycoprotein hormone receptors from mamals

AU - Vibede, N

AU - Hauser, Frank

AU - Williamson, M

AU - Grimmelikhuijzen, Cornelis

PY - 1998

Y1 - 1998

N2 - AbstractCnidarians (e.g., sea anemones and corals) are the lowest animal group having a nervous system. Previously, we cloned a receptor from sea anemones that showed a strong structural similarity to the glycoprotein hormone (TSH, FSH, LH/CG) receptors from mammals. Here, we determine the genomic organization of this sea anemone receptor. The receptor gene contains eight introns that are all localized within a region coding for the large extracellular N terminus. These introns occur at the same positions and have the same intron phasing as eight introns in the genes coding for the mammalian glycoprotein hormone receptors, indicating that the cnidarian and mammalian receptor genes are evolutionarily related. As with the mammalian receptor genes, the sea anemone receptor gene does not contain introns in the region coding for the transmembrane and intracellular domains. Southern blot analyses show that the cnidarian receptor is coded for by a single gene. *1 The nucleotide sequences reported in this paper have been deposited with the DDBJ, EMBL, and GenBank Nucleotide Sequence Databases under Accession Nos. AF084384-AF084390.

AB - AbstractCnidarians (e.g., sea anemones and corals) are the lowest animal group having a nervous system. Previously, we cloned a receptor from sea anemones that showed a strong structural similarity to the glycoprotein hormone (TSH, FSH, LH/CG) receptors from mammals. Here, we determine the genomic organization of this sea anemone receptor. The receptor gene contains eight introns that are all localized within a region coding for the large extracellular N terminus. These introns occur at the same positions and have the same intron phasing as eight introns in the genes coding for the mammalian glycoprotein hormone receptors, indicating that the cnidarian and mammalian receptor genes are evolutionarily related. As with the mammalian receptor genes, the sea anemone receptor gene does not contain introns in the region coding for the transmembrane and intracellular domains. Southern blot analyses show that the cnidarian receptor is coded for by a single gene. *1 The nucleotide sequences reported in this paper have been deposited with the DDBJ, EMBL, and GenBank Nucleotide Sequence Databases under Accession Nos. AF084384-AF084390.

U2 - 10.1006/bbrc.1998.9661

DO - 10.1006/bbrc.1998.9661

M3 - Journal article

C2 - 9826559

VL - 252

SP - 497

EP - 501

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -