Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies. / Avalos, Arián; Fang, Miaoquan; Pan, Hailin; Lluch, Aixa Ramirez; Lipka, Alexander E.; Zhao, Sihai Dave; Giray, Tugrul; Robinson, Gene E.; Zhang, Guojie; Hudson, Matthew E.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 29, 2020, p. 17135-17141.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Avalos, A, Fang, M, Pan, H, Lluch, AR, Lipka, AE, Zhao, SD, Giray, T, Robinson, GE, Zhang, G & Hudson, ME 2020, 'Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 29, pp. 17135-17141. https://doi.org/10.1073/pnas.1922927117

APA

Avalos, A., Fang, M., Pan, H., Lluch, A. R., Lipka, A. E., Zhao, S. D., Giray, T., Robinson, G. E., Zhang, G., & Hudson, M. E. (2020). Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies. Proceedings of the National Academy of Sciences of the United States of America, 117(29), 17135-17141. https://doi.org/10.1073/pnas.1922927117

Vancouver

Avalos A, Fang M, Pan H, Lluch AR, Lipka AE, Zhao SD et al. Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies. Proceedings of the National Academy of Sciences of the United States of America. 2020;117(29):17135-17141. https://doi.org/10.1073/pnas.1922927117

Author

Avalos, Arián ; Fang, Miaoquan ; Pan, Hailin ; Lluch, Aixa Ramirez ; Lipka, Alexander E. ; Zhao, Sihai Dave ; Giray, Tugrul ; Robinson, Gene E. ; Zhang, Guojie ; Hudson, Matthew E. / Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies. In: Proceedings of the National Academy of Sciences of the United States of America. 2020 ; Vol. 117, No. 29. pp. 17135-17141.

Bibtex

@article{a61e23a5b72449a2bf8a57562cb9bcf7,
title = "Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies",
abstract = "For social animals, the genotypes of group members affect the social environment, and thus individual behavior, often indirectly. We used genome-wide association studies (GWAS) to determine the influence of individual vs. group genotypes on aggression in honey bees. Aggression in honey bees arises from the coordinated actions of colony members, primarily nonreproductive {"}soldier{"} bees, and thus, experiences evolutionary selection at the colony level. Here, we show that individual behavior is influenced by colony environment, which in turn, is shaped by allele frequency within colonies. Using a population with a range of aggression, we sequenced individual whole genomes and looked for genotype-behavior associations within colonies in a common environment. There were no significant correlations between individual aggression and specific alleles. By contrast, we found strong correlations between colony aggression and the frequencies of specific alleles within colonies, despite a small number of colonies. Associations at the colony level were highly significant and were very similar among both soldiers and foragers, but they covaried with one another. One strongly significant association peak, containing an ortholog of the Drosophila sensory gene dpr4 on linkage group (chromosome) 7, showed strong signals of both selection and admixture during the evolution of gentleness in a honey bee population. We thus found links between colony genetics and group behavior and also, molec-ular evidence for group-level selection, acting at the colony level. We conclude that group genetics dominates individual genetics in deter-mining the fatal decision of honey bees to sting.",
keywords = "behavioral genetics, GWAS, aggression, DEFENSIVE BEHAVIOR, GENETIC ARCHITECTURE, FAMILY POOLS, TRAITS, ASSOCIATION, PREDICTION, INFERENCE, LOCI",
author = "Ari{\'a}n Avalos and Miaoquan Fang and Hailin Pan and Lluch, {Aixa Ramirez} and Lipka, {Alexander E.} and Zhao, {Sihai Dave} and Tugrul Giray and Robinson, {Gene E.} and Guojie Zhang and Hudson, {Matthew E.}",
year = "2020",
doi = "10.1073/pnas.1922927117",
language = "English",
volume = "117",
pages = "17135--17141",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "29",

}

RIS

TY - JOUR

T1 - Genomic regions influencing aggressive behavior in honey bees are defined by colony allele frequencies

AU - Avalos, Arián

AU - Fang, Miaoquan

AU - Pan, Hailin

AU - Lluch, Aixa Ramirez

AU - Lipka, Alexander E.

AU - Zhao, Sihai Dave

AU - Giray, Tugrul

AU - Robinson, Gene E.

AU - Zhang, Guojie

AU - Hudson, Matthew E.

PY - 2020

Y1 - 2020

N2 - For social animals, the genotypes of group members affect the social environment, and thus individual behavior, often indirectly. We used genome-wide association studies (GWAS) to determine the influence of individual vs. group genotypes on aggression in honey bees. Aggression in honey bees arises from the coordinated actions of colony members, primarily nonreproductive "soldier" bees, and thus, experiences evolutionary selection at the colony level. Here, we show that individual behavior is influenced by colony environment, which in turn, is shaped by allele frequency within colonies. Using a population with a range of aggression, we sequenced individual whole genomes and looked for genotype-behavior associations within colonies in a common environment. There were no significant correlations between individual aggression and specific alleles. By contrast, we found strong correlations between colony aggression and the frequencies of specific alleles within colonies, despite a small number of colonies. Associations at the colony level were highly significant and were very similar among both soldiers and foragers, but they covaried with one another. One strongly significant association peak, containing an ortholog of the Drosophila sensory gene dpr4 on linkage group (chromosome) 7, showed strong signals of both selection and admixture during the evolution of gentleness in a honey bee population. We thus found links between colony genetics and group behavior and also, molec-ular evidence for group-level selection, acting at the colony level. We conclude that group genetics dominates individual genetics in deter-mining the fatal decision of honey bees to sting.

AB - For social animals, the genotypes of group members affect the social environment, and thus individual behavior, often indirectly. We used genome-wide association studies (GWAS) to determine the influence of individual vs. group genotypes on aggression in honey bees. Aggression in honey bees arises from the coordinated actions of colony members, primarily nonreproductive "soldier" bees, and thus, experiences evolutionary selection at the colony level. Here, we show that individual behavior is influenced by colony environment, which in turn, is shaped by allele frequency within colonies. Using a population with a range of aggression, we sequenced individual whole genomes and looked for genotype-behavior associations within colonies in a common environment. There were no significant correlations between individual aggression and specific alleles. By contrast, we found strong correlations between colony aggression and the frequencies of specific alleles within colonies, despite a small number of colonies. Associations at the colony level were highly significant and were very similar among both soldiers and foragers, but they covaried with one another. One strongly significant association peak, containing an ortholog of the Drosophila sensory gene dpr4 on linkage group (chromosome) 7, showed strong signals of both selection and admixture during the evolution of gentleness in a honey bee population. We thus found links between colony genetics and group behavior and also, molec-ular evidence for group-level selection, acting at the colony level. We conclude that group genetics dominates individual genetics in deter-mining the fatal decision of honey bees to sting.

KW - behavioral genetics

KW - GWAS

KW - aggression

KW - DEFENSIVE BEHAVIOR

KW - GENETIC ARCHITECTURE

KW - FAMILY POOLS

KW - TRAITS

KW - ASSOCIATION

KW - PREDICTION

KW - INFERENCE

KW - LOCI

U2 - 10.1073/pnas.1922927117

DO - 10.1073/pnas.1922927117

M3 - Journal article

C2 - 32631983

VL - 117

SP - 17135

EP - 17141

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 29

ER -

ID: 246822545