Immunomodulation by LongoVital in patients with recurrent aphthous ulceration
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Immunomodulation by LongoVital in patients with recurrent aphthous ulceration. / Pedersen, A; Klausen, B; Hougen, H P; Ryder, L; Winther, K.
In: Journal of Oral Pathology & Medicine, Vol. 19, No. 8, 1990, p. 376-80.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Immunomodulation by LongoVital in patients with recurrent aphthous ulceration
AU - Pedersen, A
AU - Klausen, B
AU - Hougen, H P
AU - Ryder, L
AU - Winther, K
PY - 1990
Y1 - 1990
N2 - LongoVital (LV) (DK. Reg. No. 5178/75) is a herbal based tablet enriched with recommended doses of vitamins. Peripheral lymphocyte subsets: T-helper/CD4 (OKT4+) and T-suppressor/cytotoxic/CD8 (OKT8+) were studied quantitatively in 31 otherwise healthy patients with minor recurrent aphthous ulceration (RAU) during 6 months' daily LV intake in a double-blind, randomized, crossover 1-year study. Fourteen had had LV during the first 6 months (GrA) and 17 LV during the latter 6 months (GrB). OKT4+ percentages increased significantly during the LV period in both groups (P less than 0.05). OKT8+ percentages increased in both groups, however, only significantly in GrA (P less than 0.05). It is concluded that LV acts as an immunostimulator in patients with RAU and that the increase in T-lymphocyte subsets may account for the previously reported benefit of LV in RAU prevention.
AB - LongoVital (LV) (DK. Reg. No. 5178/75) is a herbal based tablet enriched with recommended doses of vitamins. Peripheral lymphocyte subsets: T-helper/CD4 (OKT4+) and T-suppressor/cytotoxic/CD8 (OKT8+) were studied quantitatively in 31 otherwise healthy patients with minor recurrent aphthous ulceration (RAU) during 6 months' daily LV intake in a double-blind, randomized, crossover 1-year study. Fourteen had had LV during the first 6 months (GrA) and 17 LV during the latter 6 months (GrB). OKT4+ percentages increased significantly during the LV period in both groups (P less than 0.05). OKT8+ percentages increased in both groups, however, only significantly in GrA (P less than 0.05). It is concluded that LV acts as an immunostimulator in patients with RAU and that the increase in T-lymphocyte subsets may account for the previously reported benefit of LV in RAU prevention.
KW - Adult
KW - Aged
KW - Analysis of Variance
KW - CD4-Positive T-Lymphocytes
KW - Double-Blind Method
KW - Female
KW - Humans
KW - Killer Cells, Natural
KW - Lymphocyte Activation
KW - Male
KW - Middle Aged
KW - Phytotherapy
KW - Recurrence
KW - Stomatitis, Aphthous
KW - T-Lymphocytes, Helper-Inducer
KW - T-Lymphocytes, Regulatory
KW - Ulcer
M3 - Journal article
C2 - 1979083
VL - 19
SP - 376
EP - 380
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
SN - 0904-2512
IS - 8
ER -
ID: 44354788