Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism
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Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism. / Hu, Xiangwei; Xia, Kai; Dai, Minhui; Han, Xiaofeng; Yuan, Peng; Liu, Jia; Liu, Shiwei; Jia, Fuhuai; Chen, Jiayu; Jiang, Fangfang; Yu, Jieyao; Yang, Huanming; Wang, Jian; Xu, Xun; Jin, Xin; Kristiansen, Karsten; Xiao, Liang; Chen, Wei; Han, Mo; Duan, Shenglin.
In: npj Biofilms and Microbiomes, Vol. 9, No. 1, 19, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism
AU - Hu, Xiangwei
AU - Xia, Kai
AU - Dai, Minhui
AU - Han, Xiaofeng
AU - Yuan, Peng
AU - Liu, Jia
AU - Liu, Shiwei
AU - Jia, Fuhuai
AU - Chen, Jiayu
AU - Jiang, Fangfang
AU - Yu, Jieyao
AU - Yang, Huanming
AU - Wang, Jian
AU - Xu, Xun
AU - Jin, Xin
AU - Kristiansen, Karsten
AU - Xiao, Liang
AU - Chen, Wei
AU - Han, Mo
AU - Duan, Shenglin
N1 - Publisher Copyright: © 2023. The Author(s).
PY - 2023
Y1 - 2023
N2 - Intermittent fasting (IF) is a promising paradigm for weight loss which has been shown to modulate the gut microbiota based on 16S rRNA gene amplicon sequencing. Here, 72 Chinese volunteers with a wide range of body mass index (BMI) participated in a three-week IF program during which an average loss of 3.67 kg body weight accompanied with improved clinical parameters was observed irrespective of initial anthropometric and gut microbiota status. Fecal samples were collected before and after the intervention and subjected to shotgun metagenomic sequencing. De novo assembly yielded 2934 metagenome-assembled genomes (MAGs). Profiling revealed significant enrichment of Parabacteroides distasonis and Bacteroides thetaiotaomicron after the intervention, with inverse correlations between their relative abundances and parameters related to obesity and atherosclerotic cardiovascular diseases (ASCVD). MAGs enriched after the intervention showed high richness and diversity of carbohydrate-active enzymes, with an increased relative abundances of genes related to succinate production and glutamate fermentation.
AB - Intermittent fasting (IF) is a promising paradigm for weight loss which has been shown to modulate the gut microbiota based on 16S rRNA gene amplicon sequencing. Here, 72 Chinese volunteers with a wide range of body mass index (BMI) participated in a three-week IF program during which an average loss of 3.67 kg body weight accompanied with improved clinical parameters was observed irrespective of initial anthropometric and gut microbiota status. Fecal samples were collected before and after the intervention and subjected to shotgun metagenomic sequencing. De novo assembly yielded 2934 metagenome-assembled genomes (MAGs). Profiling revealed significant enrichment of Parabacteroides distasonis and Bacteroides thetaiotaomicron after the intervention, with inverse correlations between their relative abundances and parameters related to obesity and atherosclerotic cardiovascular diseases (ASCVD). MAGs enriched after the intervention showed high richness and diversity of carbohydrate-active enzymes, with an increased relative abundances of genes related to succinate production and glutamate fermentation.
U2 - 10.1038/s41522-023-00386-4
DO - 10.1038/s41522-023-00386-4
M3 - Journal article
C2 - 37029135
AN - SCOPUS:85152029797
VL - 9
JO - n p j Biofilms and Microbomes
JF - n p j Biofilms and Microbomes
SN - 2055-5008
IS - 1
M1 - 19
ER -
ID: 343300706