Osmosensory mechanisms in cellular and systemic volume regulation
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Osmosensory mechanisms in cellular and systemic volume regulation. / Pedersen, Stine Helene Falsig; Kapus, András; Hoffmann, Else K.
In: Journal of the American Society of Nephrology, Vol. 22, No. 9, 2011, p. 1587-97.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Osmosensory mechanisms in cellular and systemic volume regulation
AU - Pedersen, Stine Helene Falsig
AU - Kapus, András
AU - Hoffmann, Else K
PY - 2011
Y1 - 2011
N2 - Perturbations of cellular and systemic osmolarity severely challenge the function of all organisms and are consequently regulated very tightly. Here we outline current evidence on how cells sense volume perturbations, with particular focus on mechanisms relevant to the kidneys and to extracellular osmolarity and whole body volume homeostasis. There are a variety of molecular signals that respond to perturbations in cell volume and osmosensors or volume sensors responding to these signals. The early signals of volume perturbation include integrins, the cytoskeleton, receptor tyrosine kinases, and transient receptor potential channels. We also present current evidence on the localization and function of central and peripheral systemic osmosensors and conclude with a brief look at the still limited evidence on pathophysiological conditions associated with deranged sensing of cell volume.
AB - Perturbations of cellular and systemic osmolarity severely challenge the function of all organisms and are consequently regulated very tightly. Here we outline current evidence on how cells sense volume perturbations, with particular focus on mechanisms relevant to the kidneys and to extracellular osmolarity and whole body volume homeostasis. There are a variety of molecular signals that respond to perturbations in cell volume and osmosensors or volume sensors responding to these signals. The early signals of volume perturbation include integrins, the cytoskeleton, receptor tyrosine kinases, and transient receptor potential channels. We also present current evidence on the localization and function of central and peripheral systemic osmosensors and conclude with a brief look at the still limited evidence on pathophysiological conditions associated with deranged sensing of cell volume.
KW - Cell Size
KW - Homeostasis
KW - Kidney
KW - Macrophages
KW - Mechanotransduction, Cellular
KW - Osmolar Concentration
U2 - 10.1681/ASN.2010121284
DO - 10.1681/ASN.2010121284
M3 - Journal article
C2 - 21852585
VL - 22
SP - 1587
EP - 1597
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
SN - 1046-6673
IS - 9
ER -
ID: 36070017