TY - JOUR

T1 - Parallel evolution of fish bi-modal breathing and expansion of olfactory receptor (OR) genes

T2 - toward a universal ORs nomenclature

AU - Silva, Liliana

AU - Mendes, Tito

AU - Ramos, Luana

AU - Zhang, Guojie

AU - Antunes, Agostinho

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - Olfactory receptors (ORs) play a key role in the prime sensorial perception, being highly relevant for intra/interspecific interactions. ORs are a subgroup of G-protein coupled receptors that exhibit highly complex subgenomes in vertebrates. However, OR repertoires remain poorly studied in fish lineages, precluding finely retracing their origin, evolution, and diversification, especially in the most basal groups. Here, we conducted an exhaustive gene screening upon 43 high-quality fish genomes exhibiting varied gene repertoires (2–583 genes). While the early vertebrates performed gas exchange through gills, we hypothesize that the emergence of new breathing structures (swim bladder and paired lungs) in early osteichthyans may be associated with expansions in the ORs gene families sensitive to airborne molecules. Additionally, we verified that the OR repertoire of moderns actinopterygians has not increased as expected following a whole genome duplication, likely due to regulatory mechanisms compensating the gene load excess. Finally, we identified 25 distinct OR families, allowing us to propose an updated universal nomenclature for the fish ORs.

AB - Olfactory receptors (ORs) play a key role in the prime sensorial perception, being highly relevant for intra/interspecific interactions. ORs are a subgroup of G-protein coupled receptors that exhibit highly complex subgenomes in vertebrates. However, OR repertoires remain poorly studied in fish lineages, precluding finely retracing their origin, evolution, and diversification, especially in the most basal groups. Here, we conducted an exhaustive gene screening upon 43 high-quality fish genomes exhibiting varied gene repertoires (2–583 genes). While the early vertebrates performed gas exchange through gills, we hypothesize that the emergence of new breathing structures (swim bladder and paired lungs) in early osteichthyans may be associated with expansions in the ORs gene families sensitive to airborne molecules. Additionally, we verified that the OR repertoire of moderns actinopterygians has not increased as expected following a whole genome duplication, likely due to regulatory mechanisms compensating the gene load excess. Finally, we identified 25 distinct OR families, allowing us to propose an updated universal nomenclature for the fish ORs.

KW - Bi-modal breathing

KW - Fish OR repertoires

KW - ORs expansion

KW - Updated ORs nomenclature

KW - WGD and ORs diversification

U2 - 10.1016/j.jgg.2023.03.006

DO - 10.1016/j.jgg.2023.03.006

M3 - Journal article

C2 - 36935037

AN - SCOPUS:85152640220

VL - 50

JO - Journal of Genetics and Genomics

JF - Journal of Genetics and Genomics

SN - 1673-8527

IS - 8

ER -