The cellular 3D printer of a marine bristle worm—chaetogenesis in Platynereis dumerilii (Audouin & Milne Edwards, 1834) (Annelida)
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The cellular 3D printer of a marine bristle worm—chaetogenesis in Platynereis dumerilii (Audouin & Milne Edwards, 1834) (Annelida). / Tilic, Ekin; Herkenrath, Tim; Kirfel, Gregor; Bartolomaeus, Thomas.
In: Cell and Tissue Research, Vol. 391, 2023, p. 305-322.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - The cellular 3D printer of a marine bristle worm—chaetogenesis in Platynereis dumerilii (Audouin & Milne Edwards, 1834) (Annelida)
AU - Tilic, Ekin
AU - Herkenrath, Tim
AU - Kirfel, Gregor
AU - Bartolomaeus, Thomas
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2023
Y1 - 2023
N2 - Annelid chaetae are extracellular chitinous structures that are formed in an extracellular epidermal invagination, the chaetal follicle. The basalmost cell of this follicle, the chaetoblast, serves like a 3D-printer as it dynamically shapes the chaeta. During chaetogenesis apical microvilli of the chaetoblast form the template for the chaeta, any structural details result from modulating the microvilli pattern. This study describes this process in detail in the model organism Platynereis dumerilii and clarifies some aspects of chaetogenesis in its close relative Nereis vexillosa, the first annelid in which the ultrastructure of chaetogenesis had been described. Nereid species possess compound chaetae characteristic for numerous subgroups of errant annelids. The distal most section of these chaetae is movable; a hinge connects this part of the chaeta to the shaft. Modulation of the microvilli and differences in their structure, diameter and number of microvilli, and their withdrawal and reappearance determine the shape of these compound chaetae. Chaetal structure and pattern also change during life history. While larvae possess a single type of chaeta (in addition to internal aciculae), juveniles and adults possess two types of chaetae that are replaced by large paddle-shaped chaetae in swimming epitokous stages. Chaetogenesis is a continuous process that lasts during the entire lifespan. The detailed developmental sequence of chaetae and their site of formation are very similar within species and species groups. We expect that similarity results from a conserved gene regulatory network making this an optimal system to test the phylogenetic affinity of taxa and the homology of their chaetae.
AB - Annelid chaetae are extracellular chitinous structures that are formed in an extracellular epidermal invagination, the chaetal follicle. The basalmost cell of this follicle, the chaetoblast, serves like a 3D-printer as it dynamically shapes the chaeta. During chaetogenesis apical microvilli of the chaetoblast form the template for the chaeta, any structural details result from modulating the microvilli pattern. This study describes this process in detail in the model organism Platynereis dumerilii and clarifies some aspects of chaetogenesis in its close relative Nereis vexillosa, the first annelid in which the ultrastructure of chaetogenesis had been described. Nereid species possess compound chaetae characteristic for numerous subgroups of errant annelids. The distal most section of these chaetae is movable; a hinge connects this part of the chaeta to the shaft. Modulation of the microvilli and differences in their structure, diameter and number of microvilli, and their withdrawal and reappearance determine the shape of these compound chaetae. Chaetal structure and pattern also change during life history. While larvae possess a single type of chaeta (in addition to internal aciculae), juveniles and adults possess two types of chaetae that are replaced by large paddle-shaped chaetae in swimming epitokous stages. Chaetogenesis is a continuous process that lasts during the entire lifespan. The detailed developmental sequence of chaetae and their site of formation are very similar within species and species groups. We expect that similarity results from a conserved gene regulatory network making this an optimal system to test the phylogenetic affinity of taxa and the homology of their chaetae.
KW - Chitin
KW - Microvilli
KW - Morphogenesis
KW - Polychaeta
KW - Ultrastructure
U2 - 10.1007/s00441-022-03731-9
DO - 10.1007/s00441-022-03731-9
M3 - Journal article
C2 - 36562865
AN - SCOPUS:85144706129
VL - 391
SP - 305
EP - 322
JO - Cell and Tissue Research
JF - Cell and Tissue Research
SN - 0302-766X
ER -
ID: 333766957