The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

Research output: Contribution to journal › Journal article › Research › peer-review

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The European Research Network on Signal Transduction (ERNEST) : Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. / Sommer, Martha E; Selent, Jana; Carlsson, Jens; De Graaf, Chris; Gloriam, David E; Keseru, Gyorgy M; Kosloff, Mickey; Mordalski, Stefan; Rizk, Aurelien; Rosenkilde, Mette M.; Sotelo, Eddy; Tiemann, Johanna K. S.; Tobin, Andrew; Vardjan, Nina; Waldhoer, Maria; Kolb, Peter.

In: ACS Pharmacology & Translational Science, Vol. 3, No. 2, 2020, p. 361-370.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sommer, ME, Selent, J, Carlsson, J, De Graaf, C, Gloriam, DE, Keseru, GM, Kosloff, M, Mordalski, S, Rizk, A, Rosenkilde, MM, Sotelo, E, Tiemann, JKS, Tobin, A, Vardjan, N, Waldhoer, M & Kolb, P 2020, 'The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling', ACS Pharmacology & Translational Science, vol. 3, no. 2, pp. 361-370. https://doi.org/10.1021/acsptsci.0c00024

APA

Sommer, M. E., Selent, J., Carlsson, J., De Graaf, C., Gloriam, D. E., Keseru, G. M., Kosloff, M., Mordalski, S., Rizk, A., Rosenkilde, M. M., Sotelo, E., Tiemann, J. K. S., Tobin, A., Vardjan, N., Waldhoer, M., & Kolb, P. (2020). The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. ACS Pharmacology & Translational Science, 3(2), 361-370. https://doi.org/10.1021/acsptsci.0c00024

Vancouver

Sommer ME, Selent J, Carlsson J, De Graaf C, Gloriam DE, Keseru GM et al. The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. ACS Pharmacology & Translational Science. 2020;3(2):361-370. https://doi.org/10.1021/acsptsci.0c00024

Author

Sommer, Martha E ; Selent, Jana ; Carlsson, Jens ; De Graaf, Chris ; Gloriam, David E ; Keseru, Gyorgy M ; Kosloff, Mickey ; Mordalski, Stefan ; Rizk, Aurelien ; Rosenkilde, Mette M. ; Sotelo, Eddy ; Tiemann, Johanna K. S. ; Tobin, Andrew ; Vardjan, Nina ; Waldhoer, Maria ; Kolb, Peter. / The European Research Network on Signal Transduction (ERNEST) : Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling. In: ACS Pharmacology & Translational Science. 2020 ; Vol. 3, No. 2. pp. 361-370.

Bibtex

@article{799d81fdb38c4112bee26c0400bd0425,
title = "The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling",
abstract = "G protein-coupled receptors (GPCRs) are intensively studied due to their therapeutic potential as drug targets. Members of this large family of transmembrane receptor proteins mediate signal transduction in diverse cell types and play key roles in human physiology and health. In 2013 the research consortium GLISTEN (COST Action CM1207) was founded with the goal of harnessing the substantial growth in knowledge of GPCR structure and dynamics to push forward the development of molecular modulators of GPCR function. The success of GLISTEN, coupled with new findings and paradigm shifts in the field, led in 2019 to the creation of a related consortium called ERNEST (COST Action CA18133). ERNEST broadens focus to entire signaling cascades, based on emerging ideas of how complexity and specificity in signal transduction are not determined by receptor-ligand interactions alone. A holistic approach that unites the diverse data and perspectives of the research community into a single multidimensional map holds great promise for improved drug design and therapeutic targeting.",
author = "Sommer, {Martha E} and Jana Selent and Jens Carlsson and {De Graaf}, Chris and Gloriam, {David E} and Keseru, {Gyorgy M} and Mickey Kosloff and Stefan Mordalski and Aurelien Rizk and Rosenkilde, {Mette M.} and Eddy Sotelo and Tiemann, {Johanna K. S.} and Andrew Tobin and Nina Vardjan and Maria Waldhoer and Peter Kolb",
note = "Copyright {\textcopyright} 2020 American Chemical Society.",
year = "2020",
doi = "10.1021/acsptsci.0c00024",
language = "English",
volume = "3",
pages = "361--370",
journal = "ACS Pharmacology and Translational Science",
issn = "2575-9108",
publisher = "ACS Publications",
number = "2",

}

RIS

TY - JOUR

T1 - The European Research Network on Signal Transduction (ERNEST)

T2 - Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

AU - Sommer, Martha E

AU - Selent, Jana

AU - Carlsson, Jens

AU - De Graaf, Chris

AU - Gloriam, David E

AU - Keseru, Gyorgy M

AU - Kosloff, Mickey

AU - Mordalski, Stefan

AU - Rizk, Aurelien

AU - Rosenkilde, Mette M.

AU - Sotelo, Eddy

AU - Tiemann, Johanna K. S.

AU - Tobin, Andrew

AU - Vardjan, Nina

AU - Waldhoer, Maria

AU - Kolb, Peter

N1 - Copyright © 2020 American Chemical Society.

PY - 2020

Y1 - 2020

N2 - G protein-coupled receptors (GPCRs) are intensively studied due to their therapeutic potential as drug targets. Members of this large family of transmembrane receptor proteins mediate signal transduction in diverse cell types and play key roles in human physiology and health. In 2013 the research consortium GLISTEN (COST Action CM1207) was founded with the goal of harnessing the substantial growth in knowledge of GPCR structure and dynamics to push forward the development of molecular modulators of GPCR function. The success of GLISTEN, coupled with new findings and paradigm shifts in the field, led in 2019 to the creation of a related consortium called ERNEST (COST Action CA18133). ERNEST broadens focus to entire signaling cascades, based on emerging ideas of how complexity and specificity in signal transduction are not determined by receptor-ligand interactions alone. A holistic approach that unites the diverse data and perspectives of the research community into a single multidimensional map holds great promise for improved drug design and therapeutic targeting.

AB - G protein-coupled receptors (GPCRs) are intensively studied due to their therapeutic potential as drug targets. Members of this large family of transmembrane receptor proteins mediate signal transduction in diverse cell types and play key roles in human physiology and health. In 2013 the research consortium GLISTEN (COST Action CM1207) was founded with the goal of harnessing the substantial growth in knowledge of GPCR structure and dynamics to push forward the development of molecular modulators of GPCR function. The success of GLISTEN, coupled with new findings and paradigm shifts in the field, led in 2019 to the creation of a related consortium called ERNEST (COST Action CA18133). ERNEST broadens focus to entire signaling cascades, based on emerging ideas of how complexity and specificity in signal transduction are not determined by receptor-ligand interactions alone. A holistic approach that unites the diverse data and perspectives of the research community into a single multidimensional map holds great promise for improved drug design and therapeutic targeting.

U2 - 10.1021/acsptsci.0c00024

DO - 10.1021/acsptsci.0c00024

M3 - Journal article

C2 - 32296774

VL - 3

SP - 361

EP - 370

JO - ACS Pharmacology and Translational Science

JF - ACS Pharmacology and Translational Science

SN - 2575-9108

IS - 2

ER -

ID: 240247736