The extrachromosomal circular DNA atlas of aged and young mouse brains
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The extrachromosomal circular DNA atlas of aged and young mouse brains. / Hong, Xiaoning; Li, Jing; Han, Peng; Li, Shaofu; Yu, Jiaying; Zhang, Haoran; Li, Jiang; Dang, Yonghui; Xiang, Xi.
In: Scientific Data, Vol. 11, No. 1, 318, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The extrachromosomal circular DNA atlas of aged and young mouse brains
AU - Hong, Xiaoning
AU - Li, Jing
AU - Han, Peng
AU - Li, Shaofu
AU - Yu, Jiaying
AU - Zhang, Haoran
AU - Li, Jiang
AU - Dang, Yonghui
AU - Xiang, Xi
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation, progression, and evolutionary processes. However, the relationship between eccDNA and brain aging remains elusive. Here, we employed extrachromosomal circular DNA sequencing (Circle-seq) to generate a comprehensive dataset of eccDNA from six brain structures of both young and naturally-aged mice, including the olfactory bulb, medial prefrontal cortex, nucleus accumbens, caudate putamen, hippocampus, and cerebellum. Furthermore, through database annotation, we characterized the properties of mouse brain eccDNA, thereby gaining insights into the potential functions of eccDNA in the mouse brain. In conclusion, our study addresses a previously unexplored area by providing a comprehensive molecular characterization of eccDNA in brain tissues. The data presented in the study can be used as a fundamental resource to associate the molecular phenotypes of eccDNA with brain aging and gain deep insights into the biological role of eccDNA in mammalian brain aging.
AB - Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation, progression, and evolutionary processes. However, the relationship between eccDNA and brain aging remains elusive. Here, we employed extrachromosomal circular DNA sequencing (Circle-seq) to generate a comprehensive dataset of eccDNA from six brain structures of both young and naturally-aged mice, including the olfactory bulb, medial prefrontal cortex, nucleus accumbens, caudate putamen, hippocampus, and cerebellum. Furthermore, through database annotation, we characterized the properties of mouse brain eccDNA, thereby gaining insights into the potential functions of eccDNA in the mouse brain. In conclusion, our study addresses a previously unexplored area by providing a comprehensive molecular characterization of eccDNA in brain tissues. The data presented in the study can be used as a fundamental resource to associate the molecular phenotypes of eccDNA with brain aging and gain deep insights into the biological role of eccDNA in mammalian brain aging.
U2 - 10.1038/s41597-024-03146-x
DO - 10.1038/s41597-024-03146-x
M3 - Journal article
C2 - 38538648
AN - SCOPUS:85189150036
VL - 11
JO - Scientific data
JF - Scientific data
SN - 2052-4463
IS - 1
M1 - 318
ER -
ID: 387835676