The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions. / Liu, Yawen; Gao, Hui; Marstrand, Troels Torben; Ström, Anders; Valen, Eivind; Sandelin, Albin; Gustafsson, Jan-Åke; Dahlman-Wright, Karin.

In: Proceedings of the National Academy of Science of the United States of America, 2008.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Liu, Y, Gao, H, Marstrand, TT, Ström, A, Valen, E, Sandelin, A, Gustafsson, J-Å & Dahlman-Wright, K 2008, 'The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions.', Proceedings of the National Academy of Science of the United States of America. https://doi.org/10.1073/pnas.0712085105

APA

Liu, Y., Gao, H., Marstrand, T. T., Ström, A., Valen, E., Sandelin, A., Gustafsson, J-Å., & Dahlman-Wright, K. (2008). The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions. Proceedings of the National Academy of Science of the United States of America. https://doi.org/10.1073/pnas.0712085105

Vancouver

Liu Y, Gao H, Marstrand TT, Ström A, Valen E, Sandelin A et al. The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions. Proceedings of the National Academy of Science of the United States of America. 2008. https://doi.org/10.1073/pnas.0712085105

Author

Liu, Yawen ; Gao, Hui ; Marstrand, Troels Torben ; Ström, Anders ; Valen, Eivind ; Sandelin, Albin ; Gustafsson, Jan-Åke ; Dahlman-Wright, Karin. / The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions. In: Proceedings of the National Academy of Science of the United States of America. 2008.

Bibtex

@article{43461c90de3a11dcbee902004c4f4f50,
title = "The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions.",
abstract = "In this article, we have applied the ChIP-on-chip approach to pursue a large scale identification of ERalpha- and ERbeta-binding DNA regions in intact chromatin. We show that there is a high degree of overlap between the regions identified as bound by ERalpha and ERbeta, respectively, but there are also regions that are bound by ERalpha only in the presence of ERbeta, as well as regions that are selectively bound by either receptor. Analysis of bound regions shows that regions bound by ERalpha have distinct properties in terms of genome landscape, sequence features, and conservation compared with regions that are bound by ERbeta. ERbeta-bound regions are, as a group, located more closely to transcription start sites. ERalpha- and ERbeta-bound regions differ in sequence properties, with ERalpha-bound regions having an overrepresentation of TA-rich motifs including forkhead binding sites and ERbeta-bound regions having a predominance of classical estrogen response elements (EREs) and GC-rich motifs. Differences in the properties of ER bound regions might explain some of the differences in gene expression programs and physiological effects shown by the respective estrogen receptors. Udgivelsesdato: 2008-Feb-13",
author = "Yawen Liu and Hui Gao and Marstrand, {Troels Torben} and Anders Str{\"o}m and Eivind Valen and Albin Sandelin and Jan-{\AA}ke Gustafsson and Karin Dahlman-Wright",
year = "2008",
doi = "10.1073/pnas.0712085105",
language = "English",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",

}

RIS

TY - JOUR

T1 - The genome landscape of ER{alpha}- and ER{beta}-binding DNA regions.

AU - Liu, Yawen

AU - Gao, Hui

AU - Marstrand, Troels Torben

AU - Ström, Anders

AU - Valen, Eivind

AU - Sandelin, Albin

AU - Gustafsson, Jan-Åke

AU - Dahlman-Wright, Karin

PY - 2008

Y1 - 2008

N2 - In this article, we have applied the ChIP-on-chip approach to pursue a large scale identification of ERalpha- and ERbeta-binding DNA regions in intact chromatin. We show that there is a high degree of overlap between the regions identified as bound by ERalpha and ERbeta, respectively, but there are also regions that are bound by ERalpha only in the presence of ERbeta, as well as regions that are selectively bound by either receptor. Analysis of bound regions shows that regions bound by ERalpha have distinct properties in terms of genome landscape, sequence features, and conservation compared with regions that are bound by ERbeta. ERbeta-bound regions are, as a group, located more closely to transcription start sites. ERalpha- and ERbeta-bound regions differ in sequence properties, with ERalpha-bound regions having an overrepresentation of TA-rich motifs including forkhead binding sites and ERbeta-bound regions having a predominance of classical estrogen response elements (EREs) and GC-rich motifs. Differences in the properties of ER bound regions might explain some of the differences in gene expression programs and physiological effects shown by the respective estrogen receptors. Udgivelsesdato: 2008-Feb-13

AB - In this article, we have applied the ChIP-on-chip approach to pursue a large scale identification of ERalpha- and ERbeta-binding DNA regions in intact chromatin. We show that there is a high degree of overlap between the regions identified as bound by ERalpha and ERbeta, respectively, but there are also regions that are bound by ERalpha only in the presence of ERbeta, as well as regions that are selectively bound by either receptor. Analysis of bound regions shows that regions bound by ERalpha have distinct properties in terms of genome landscape, sequence features, and conservation compared with regions that are bound by ERbeta. ERbeta-bound regions are, as a group, located more closely to transcription start sites. ERalpha- and ERbeta-bound regions differ in sequence properties, with ERalpha-bound regions having an overrepresentation of TA-rich motifs including forkhead binding sites and ERbeta-bound regions having a predominance of classical estrogen response elements (EREs) and GC-rich motifs. Differences in the properties of ER bound regions might explain some of the differences in gene expression programs and physiological effects shown by the respective estrogen receptors. Udgivelsesdato: 2008-Feb-13

U2 - 10.1073/pnas.0712085105

DO - 10.1073/pnas.0712085105

M3 - Journal article

C2 - 18272478

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

ER -

ID: 2796554