The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae
Research output: Contribution to journal › Journal article › Research › peer-review
Amino acid transporters of the yeast plasma membrane (permeases) belong to a family of integral membrane proteins with pronounced structural similarity. We present evidence that a member of this family, encoded by the open reading frame (ORF) YDR160w (SSY1), is required for the expression of a set of transporter genes. Thus, deletion of the SSY1 gene causes loss of leucine-inducible transcription of the amino acid permease genes BAP2, TAT1 and BAP3 (ORF YDR046c) and the peptide transporter, PTR2. D-leucine can generate the signal without entering the cell. We propose that Ssy1p is situated in the plasma membrane and is involved in sensing leucine in the medium.
Original language | English |
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Journal | Molecular Microbiology |
Volume | 27 |
Issue number | 3 |
Pages (from-to) | 643-650 |
Number of pages | 8 |
ISSN | 0950-382X |
DOIs | |
Publication status | Published - 3 Feb 1998 |
ID: 239906386