Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery. / Asmild, Margit; Oswald, Nicholas; Krzywkowski, Karen M; Friis, Søren; Jacobsen, Rasmus B; Reuter, Dirk; Taboryski, Rafael; Kutchinsky, Jonathan; Vestergaard, Ras K; Schrøder, Rikke L; Sørensen, Claus B; Bech, Morten; Korsgaard, Mads P G; Willumsen, Niels J.

In: Receptors and Channels, Vol. 9, No. 1, 2003, p. 49-58.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Asmild, M, Oswald, N, Krzywkowski, KM, Friis, S, Jacobsen, RB, Reuter, D, Taboryski, R, Kutchinsky, J, Vestergaard, RK, Schrøder, RL, Sørensen, CB, Bech, M, Korsgaard, MPG & Willumsen, NJ 2003, 'Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery', Receptors and Channels, vol. 9, no. 1, pp. 49-58.

APA

Asmild, M., Oswald, N., Krzywkowski, K. M., Friis, S., Jacobsen, R. B., Reuter, D., Taboryski, R., Kutchinsky, J., Vestergaard, R. K., Schrøder, R. L., Sørensen, C. B., Bech, M., Korsgaard, M. P. G., & Willumsen, N. J. (2003). Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery. Receptors and Channels, 9(1), 49-58.

Vancouver

Asmild M, Oswald N, Krzywkowski KM, Friis S, Jacobsen RB, Reuter D et al. Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery. Receptors and Channels. 2003;9(1):49-58.

Author

Asmild, Margit ; Oswald, Nicholas ; Krzywkowski, Karen M ; Friis, Søren ; Jacobsen, Rasmus B ; Reuter, Dirk ; Taboryski, Rafael ; Kutchinsky, Jonathan ; Vestergaard, Ras K ; Schrøder, Rikke L ; Sørensen, Claus B ; Bech, Morten ; Korsgaard, Mads P G ; Willumsen, Niels J. / Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery. In: Receptors and Channels. 2003 ; Vol. 9, No. 1. pp. 49-58.

Bibtex

@article{0616791004fc11df825d000ea68e967b,
title = "Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery",
abstract = "Effective screening of large compound libraries in ion channel drug discovery requires the development of new electrophysiological techniques with substantially increased throughputs compared to the conventional patch clamp technique. Sophion Bioscience is aiming to meet this challenge by developing two lines of automated patch clamp products, a traditional pipette-based system called Apatchi-1, and a silicon chip-based system QPatch. The degree of automation spans from semi-automation (Apatchi-1) where a trained technician interacts with the system in a limited way, to a complete automation (QPatch 96) where the system works continuously and unattended until screening of a full compound library is completed. The performance of the systems range from medium to high throughputs.",
author = "Margit Asmild and Nicholas Oswald and Krzywkowski, {Karen M} and S{\o}ren Friis and Jacobsen, {Rasmus B} and Dirk Reuter and Rafael Taboryski and Jonathan Kutchinsky and Vestergaard, {Ras K} and Schr{\o}der, {Rikke L} and S{\o}rensen, {Claus B} and Morten Bech and Korsgaard, {Mads P G} and Willumsen, {Niels J}",
note = "Keywords: Animals; Automation; Drug Design; Electrophysiology; Ion Channels; Ions; Patch-Clamp Techniques; Silicon; Software; Time Factors",
year = "2003",
language = "English",
volume = "9",
pages = "49--58",
journal = "Receptors and Channels",
issn = "1060-6823",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery

AU - Asmild, Margit

AU - Oswald, Nicholas

AU - Krzywkowski, Karen M

AU - Friis, Søren

AU - Jacobsen, Rasmus B

AU - Reuter, Dirk

AU - Taboryski, Rafael

AU - Kutchinsky, Jonathan

AU - Vestergaard, Ras K

AU - Schrøder, Rikke L

AU - Sørensen, Claus B

AU - Bech, Morten

AU - Korsgaard, Mads P G

AU - Willumsen, Niels J

N1 - Keywords: Animals; Automation; Drug Design; Electrophysiology; Ion Channels; Ions; Patch-Clamp Techniques; Silicon; Software; Time Factors

PY - 2003

Y1 - 2003

N2 - Effective screening of large compound libraries in ion channel drug discovery requires the development of new electrophysiological techniques with substantially increased throughputs compared to the conventional patch clamp technique. Sophion Bioscience is aiming to meet this challenge by developing two lines of automated patch clamp products, a traditional pipette-based system called Apatchi-1, and a silicon chip-based system QPatch. The degree of automation spans from semi-automation (Apatchi-1) where a trained technician interacts with the system in a limited way, to a complete automation (QPatch 96) where the system works continuously and unattended until screening of a full compound library is completed. The performance of the systems range from medium to high throughputs.

AB - Effective screening of large compound libraries in ion channel drug discovery requires the development of new electrophysiological techniques with substantially increased throughputs compared to the conventional patch clamp technique. Sophion Bioscience is aiming to meet this challenge by developing two lines of automated patch clamp products, a traditional pipette-based system called Apatchi-1, and a silicon chip-based system QPatch. The degree of automation spans from semi-automation (Apatchi-1) where a trained technician interacts with the system in a limited way, to a complete automation (QPatch 96) where the system works continuously and unattended until screening of a full compound library is completed. The performance of the systems range from medium to high throughputs.

M3 - Journal article

C2 - 12825298

VL - 9

SP - 49

EP - 58

JO - Receptors and Channels

JF - Receptors and Channels

SN - 1060-6823

IS - 1

ER -

ID: 17085389