Whole-genome sequence of Schistosoma haematobium

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Whole-genome sequence of Schistosoma haematobium. / Young, Neil D.; Jex, Aaron R.; Li, Bo; Liu, Shiping; Yang, Linfeng; Xiong, Zijun; Li, Yingrui; Cantacessi, Cinzia; Hall, Ross S.; Xu, Xun; Chen, Fangyuan; Wu, Xuan; Zerlotini, Adhemar; Oliveira, Guilherme; Hofmann, Andreas; Zhang, Guojie; Fang, Xiaodong; Kang, Yi; Campbell, Bronwyn E.; Loukas, Alex; Ranganathan, Shoba; Rollinson, David; Rinaldi, Gabriel; Brindley, Paul J.; Yang, Huanming; Wang, Jun; Wang, Jian; Gasser, Robin B.

In: Nature Genetics, Vol. 44, No. 2, 2012, p. 221-225.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Young, ND, Jex, AR, Li, B, Liu, S, Yang, L, Xiong, Z, Li, Y, Cantacessi, C, Hall, RS, Xu, X, Chen, F, Wu, X, Zerlotini, A, Oliveira, G, Hofmann, A, Zhang, G, Fang, X, Kang, Y, Campbell, BE, Loukas, A, Ranganathan, S, Rollinson, D, Rinaldi, G, Brindley, PJ, Yang, H, Wang, J, Wang, J & Gasser, RB 2012, 'Whole-genome sequence of Schistosoma haematobium', Nature Genetics, vol. 44, no. 2, pp. 221-225. https://doi.org/10.1038/ng.1065

APA

Young, N. D., Jex, A. R., Li, B., Liu, S., Yang, L., Xiong, Z., Li, Y., Cantacessi, C., Hall, R. S., Xu, X., Chen, F., Wu, X., Zerlotini, A., Oliveira, G., Hofmann, A., Zhang, G., Fang, X., Kang, Y., Campbell, B. E., ... Gasser, R. B. (2012). Whole-genome sequence of Schistosoma haematobium. Nature Genetics, 44(2), 221-225. https://doi.org/10.1038/ng.1065

Vancouver

Young ND, Jex AR, Li B, Liu S, Yang L, Xiong Z et al. Whole-genome sequence of Schistosoma haematobium. Nature Genetics. 2012;44(2):221-225. https://doi.org/10.1038/ng.1065

Author

Young, Neil D. ; Jex, Aaron R. ; Li, Bo ; Liu, Shiping ; Yang, Linfeng ; Xiong, Zijun ; Li, Yingrui ; Cantacessi, Cinzia ; Hall, Ross S. ; Xu, Xun ; Chen, Fangyuan ; Wu, Xuan ; Zerlotini, Adhemar ; Oliveira, Guilherme ; Hofmann, Andreas ; Zhang, Guojie ; Fang, Xiaodong ; Kang, Yi ; Campbell, Bronwyn E. ; Loukas, Alex ; Ranganathan, Shoba ; Rollinson, David ; Rinaldi, Gabriel ; Brindley, Paul J. ; Yang, Huanming ; Wang, Jun ; Wang, Jian ; Gasser, Robin B. / Whole-genome sequence of Schistosoma haematobium. In: Nature Genetics. 2012 ; Vol. 44, No. 2. pp. 221-225.

Bibtex

@article{e1fefba49bdf4f46b027660434068bbe,
title = "Whole-genome sequence of Schistosoma haematobium",
abstract = "Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.",
author = "Young, {Neil D.} and Jex, {Aaron R.} and Bo Li and Shiping Liu and Linfeng Yang and Zijun Xiong and Yingrui Li and Cinzia Cantacessi and Hall, {Ross S.} and Xun Xu and Fangyuan Chen and Xuan Wu and Adhemar Zerlotini and Guilherme Oliveira and Andreas Hofmann and Guojie Zhang and Xiaodong Fang and Yi Kang and Campbell, {Bronwyn E.} and Alex Loukas and Shoba Ranganathan and David Rollinson and Gabriel Rinaldi and Brindley, {Paul J.} and Huanming Yang and Jun Wang and Jian Wang and Gasser, {Robin B.}",
year = "2012",
doi = "10.1038/ng.1065",
language = "English",
volume = "44",
pages = "221--225",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - Whole-genome sequence of Schistosoma haematobium

AU - Young, Neil D.

AU - Jex, Aaron R.

AU - Li, Bo

AU - Liu, Shiping

AU - Yang, Linfeng

AU - Xiong, Zijun

AU - Li, Yingrui

AU - Cantacessi, Cinzia

AU - Hall, Ross S.

AU - Xu, Xun

AU - Chen, Fangyuan

AU - Wu, Xuan

AU - Zerlotini, Adhemar

AU - Oliveira, Guilherme

AU - Hofmann, Andreas

AU - Zhang, Guojie

AU - Fang, Xiaodong

AU - Kang, Yi

AU - Campbell, Bronwyn E.

AU - Loukas, Alex

AU - Ranganathan, Shoba

AU - Rollinson, David

AU - Rinaldi, Gabriel

AU - Brindley, Paul J.

AU - Yang, Huanming

AU - Wang, Jun

AU - Wang, Jian

AU - Gasser, Robin B.

PY - 2012

Y1 - 2012

N2 - Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.

AB - Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.

U2 - 10.1038/ng.1065

DO - 10.1038/ng.1065

M3 - Journal article

C2 - 22246508

AN - SCOPUS:84862777661

VL - 44

SP - 221

EP - 225

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 2

ER -

ID: 258275997