A host of armor: Prokaryotic immune strategies against mobile genetic elements

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

A host of armor : Prokaryotic immune strategies against mobile genetic elements. / Mayo-Muñoz, David; Pinilla-Redondo, Rafael; Birkholz, Nils; Fineran, Peter C.

I: Cell Reports, Bind 42, Nr. 7, 112672, 2023.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Mayo-Muñoz, D, Pinilla-Redondo, R, Birkholz, N & Fineran, PC 2023, 'A host of armor: Prokaryotic immune strategies against mobile genetic elements', Cell Reports, bind 42, nr. 7, 112672. https://doi.org/10.1016/j.celrep.2023.112672

APA

Mayo-Muñoz, D., Pinilla-Redondo, R., Birkholz, N., & Fineran, P. C. (2023). A host of armor: Prokaryotic immune strategies against mobile genetic elements. Cell Reports, 42(7), [112672]. https://doi.org/10.1016/j.celrep.2023.112672

Vancouver

Mayo-Muñoz D, Pinilla-Redondo R, Birkholz N, Fineran PC. A host of armor: Prokaryotic immune strategies against mobile genetic elements. Cell Reports. 2023;42(7). 112672. https://doi.org/10.1016/j.celrep.2023.112672

Author

Mayo-Muñoz, David ; Pinilla-Redondo, Rafael ; Birkholz, Nils ; Fineran, Peter C. / A host of armor : Prokaryotic immune strategies against mobile genetic elements. I: Cell Reports. 2023 ; Bind 42, Nr. 7.

Bibtex

@article{8a40b40140ac4e7daca2ea6a85cfc6c4,
title = "A host of armor: Prokaryotic immune strategies against mobile genetic elements",
abstract = "Prokaryotic adaptation is strongly influenced by the horizontal acquisition of beneficial traits via mobile genetic elements (MGEs), such as viruses/bacteriophages and plasmids. However, MGEs can also impose a fitness cost due to their often parasitic nature and differing evolutionary trajectories. In response, prokaryotes have evolved diverse immune mechanisms against MGEs. Recently, our understanding of the abundance and diversity of prokaryotic immune systems has greatly expanded. These defense systems can degrade the invading genetic material, inhibit genome replication, or trigger abortive infection, leading to population protection. In this review, we highlight these strategies, focusing on the most recent discoveries. The study of prokaryotic defenses not only sheds light on microbial evolution but also uncovers novel enzymatic activities with promising biotechnological applications.",
keywords = "abortive infection, CP: Microbiology, mobile genetic element, phage, plasmid, prokaryotic immune systems",
author = "David Mayo-Mu{\~n}oz and Rafael Pinilla-Redondo and Nils Birkholz and Fineran, {Peter C.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
doi = "10.1016/j.celrep.2023.112672",
language = "English",
volume = "42",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "7",

}

RIS

TY - JOUR

T1 - A host of armor

T2 - Prokaryotic immune strategies against mobile genetic elements

AU - Mayo-Muñoz, David

AU - Pinilla-Redondo, Rafael

AU - Birkholz, Nils

AU - Fineran, Peter C.

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2023

Y1 - 2023

N2 - Prokaryotic adaptation is strongly influenced by the horizontal acquisition of beneficial traits via mobile genetic elements (MGEs), such as viruses/bacteriophages and plasmids. However, MGEs can also impose a fitness cost due to their often parasitic nature and differing evolutionary trajectories. In response, prokaryotes have evolved diverse immune mechanisms against MGEs. Recently, our understanding of the abundance and diversity of prokaryotic immune systems has greatly expanded. These defense systems can degrade the invading genetic material, inhibit genome replication, or trigger abortive infection, leading to population protection. In this review, we highlight these strategies, focusing on the most recent discoveries. The study of prokaryotic defenses not only sheds light on microbial evolution but also uncovers novel enzymatic activities with promising biotechnological applications.

AB - Prokaryotic adaptation is strongly influenced by the horizontal acquisition of beneficial traits via mobile genetic elements (MGEs), such as viruses/bacteriophages and plasmids. However, MGEs can also impose a fitness cost due to their often parasitic nature and differing evolutionary trajectories. In response, prokaryotes have evolved diverse immune mechanisms against MGEs. Recently, our understanding of the abundance and diversity of prokaryotic immune systems has greatly expanded. These defense systems can degrade the invading genetic material, inhibit genome replication, or trigger abortive infection, leading to population protection. In this review, we highlight these strategies, focusing on the most recent discoveries. The study of prokaryotic defenses not only sheds light on microbial evolution but also uncovers novel enzymatic activities with promising biotechnological applications.

KW - abortive infection

KW - CP: Microbiology

KW - mobile genetic element

KW - phage

KW - plasmid

KW - prokaryotic immune systems

U2 - 10.1016/j.celrep.2023.112672

DO - 10.1016/j.celrep.2023.112672

M3 - Review

C2 - 37347666

AN - SCOPUS:85162128435

VL - 42

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 7

M1 - 112672

ER -

ID: 370796771