A host of armor: Prokaryotic immune strategies against mobile genetic elements
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Prokaryotic adaptation is strongly influenced by the horizontal acquisition of beneficial traits via mobile genetic elements (MGEs), such as viruses/bacteriophages and plasmids. However, MGEs can also impose a fitness cost due to their often parasitic nature and differing evolutionary trajectories. In response, prokaryotes have evolved diverse immune mechanisms against MGEs. Recently, our understanding of the abundance and diversity of prokaryotic immune systems has greatly expanded. These defense systems can degrade the invading genetic material, inhibit genome replication, or trigger abortive infection, leading to population protection. In this review, we highlight these strategies, focusing on the most recent discoveries. The study of prokaryotic defenses not only sheds light on microbial evolution but also uncovers novel enzymatic activities with promising biotechnological applications.
Originalsprog | Engelsk |
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Artikelnummer | 112672 |
Tidsskrift | Cell Reports |
Vol/bind | 42 |
Udgave nummer | 7 |
Antal sider | 14 |
ISSN | 2211-1247 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
We thank Leah M. Smith for useful feedback on the manuscript. Research on phage defense systems in the Fineran laboratory is supported by the Bioprotection Aotearoa and the Marsden Fund , Royal Society of New Zealand (Te Pūtea Rangahau a Marsden, Te Apārangi). D.M.-M was supported by a University of Otago Doctoral Scholarship and a Postgraduate Publishing Bursary. R.P.-R. was supported by a Lundbeck Foundation grant ( R347-2020-2346 ). We apologize to all authors whose work we were unable to cite due to referencing constraints.
Publisher Copyright:
© 2023 The Author(s)
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