Cell transcriptomic atlas of the non-human primate Macaca fascicularis
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Cell transcriptomic atlas of the non-human primate Macaca fascicularis. / Han, Lei; Wei, Xiaoyu; Liu, Chuanyu; Volpe, Giacomo; Zhuang, Zhenkun; Zou, Xuanxuan; Wang, Zhifeng; Pan, Taotao; Yuan, Yue; Zhang, Xiao; Fan, Peng; Guo, Pengcheng; Lai, Yiwei; Lei, Ying; Liu, Xingyuan; Yu, Feng; Shangguan, Shuncheng; Lai, Guangyao; Deng, Qiuting; Liu, Ya; Wu, Liang; Shi, Quan; Yu, Hao; Huang, Yunting; Cheng, Mengnan; Xu, Jiangshan; Liu, Yang; Wang, Mingyue; Wang, Chunqing; Zhang, Yuanhang; Xie, Duo; Yang, Yunzhi; Yu, Yeya; Zheng, Huiwen; Wei, Yanrong; Huang, Fubaoqian; Lei, Junjie; Huang, Waidong; Zhu, Zhiyong; Lu, Haorong; Wang, Bo; Wei, Xiaofeng; Chen, Fengzhen; Yang, Tao; Du, Wensi; Chen, Jing; Xu, Shibo; An, Juan; Ward, Carl; Wang, Zongren; Pei, Zhong; Wong, Chi-Wai; Liu, Xiaolei; Zhang, Huafeng; Liu, Mingyuan; Qin, Baoming; Schambach, Axel; Isern, Joan; Feng, Liqiang; Liu, Yan; Guo, Xiangyu; Liu, Zhen; Sun, Qiang; Maxwell, Patrick H.; Barker, Nick; Muñoz-Cánoves, Pura; Gu, Ying; Mulder, Jan; Uhlen, Mathias; Tan, Tao; Liu, Shiping; Yang, Huanming; Wang, Jian; Hou, Yong; Xu, Xun; Esteban, Miguel A.; Liu, Longqi.
I: Nature, Bind 604, 2022, s. 723-731.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cell transcriptomic atlas of the non-human primate Macaca fascicularis
AU - Han, Lei
AU - Wei, Xiaoyu
AU - Liu, Chuanyu
AU - Volpe, Giacomo
AU - Zhuang, Zhenkun
AU - Zou, Xuanxuan
AU - Wang, Zhifeng
AU - Pan, Taotao
AU - Yuan, Yue
AU - Zhang, Xiao
AU - Fan, Peng
AU - Guo, Pengcheng
AU - Lai, Yiwei
AU - Lei, Ying
AU - Liu, Xingyuan
AU - Yu, Feng
AU - Shangguan, Shuncheng
AU - Lai, Guangyao
AU - Deng, Qiuting
AU - Liu, Ya
AU - Wu, Liang
AU - Shi, Quan
AU - Yu, Hao
AU - Huang, Yunting
AU - Cheng, Mengnan
AU - Xu, Jiangshan
AU - Liu, Yang
AU - Wang, Mingyue
AU - Wang, Chunqing
AU - Zhang, Yuanhang
AU - Xie, Duo
AU - Yang, Yunzhi
AU - Yu, Yeya
AU - Zheng, Huiwen
AU - Wei, Yanrong
AU - Huang, Fubaoqian
AU - Lei, Junjie
AU - Huang, Waidong
AU - Zhu, Zhiyong
AU - Lu, Haorong
AU - Wang, Bo
AU - Wei, Xiaofeng
AU - Chen, Fengzhen
AU - Yang, Tao
AU - Du, Wensi
AU - Chen, Jing
AU - Xu, Shibo
AU - An, Juan
AU - Ward, Carl
AU - Wang, Zongren
AU - Pei, Zhong
AU - Wong, Chi-Wai
AU - Liu, Xiaolei
AU - Zhang, Huafeng
AU - Liu, Mingyuan
AU - Qin, Baoming
AU - Schambach, Axel
AU - Isern, Joan
AU - Feng, Liqiang
AU - Liu, Yan
AU - Guo, Xiangyu
AU - Liu, Zhen
AU - Sun, Qiang
AU - Maxwell, Patrick H.
AU - Barker, Nick
AU - Muñoz-Cánoves, Pura
AU - Gu, Ying
AU - Mulder, Jan
AU - Uhlen, Mathias
AU - Tan, Tao
AU - Liu, Shiping
AU - Yang, Huanming
AU - Wang, Jian
AU - Hou, Yong
AU - Xu, Xun
AU - Esteban, Miguel A.
AU - Liu, Longqi
N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2022
Y1 - 2022
N2 - Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.
AB - Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.
U2 - 10.1038/s41586-022-04587-3
DO - 10.1038/s41586-022-04587-3
M3 - Journal article
C2 - 35418686
AN - SCOPUS:85127941630
VL - 604
SP - 723
EP - 731
JO - Nature
JF - Nature
SN - 0028-0836
ER -
ID: 303802384