Persistence and progression of staphylococcal infection in the presence of public goods

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Persistence and progression of staphylococcal infection in the presence of public goods. / Trivedi, Urvish; Fell, Cody; Madsen, Jonas S.; Everett, Jake; Burmølle, Mette; Rumbaugh, Kendra P.; Sørensen, Søren J.

I: npj Biofilms and Microbiomes, Bind 6, 55, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Trivedi, U, Fell, C, Madsen, JS, Everett, J, Burmølle, M, Rumbaugh, KP & Sørensen, SJ 2020, 'Persistence and progression of staphylococcal infection in the presence of public goods', npj Biofilms and Microbiomes, bind 6, 55. https://doi.org/10.1038/s41522-020-00168-2

APA

Trivedi, U., Fell, C., Madsen, J. S., Everett, J., Burmølle, M., Rumbaugh, K. P., & Sørensen, S. J. (2020). Persistence and progression of staphylococcal infection in the presence of public goods. npj Biofilms and Microbiomes, 6, [55]. https://doi.org/10.1038/s41522-020-00168-2

Vancouver

Trivedi U, Fell C, Madsen JS, Everett J, Burmølle M, Rumbaugh KP o.a. Persistence and progression of staphylococcal infection in the presence of public goods. npj Biofilms and Microbiomes. 2020;6. 55. https://doi.org/10.1038/s41522-020-00168-2

Author

Trivedi, Urvish ; Fell, Cody ; Madsen, Jonas S. ; Everett, Jake ; Burmølle, Mette ; Rumbaugh, Kendra P. ; Sørensen, Søren J. / Persistence and progression of staphylococcal infection in the presence of public goods. I: npj Biofilms and Microbiomes. 2020 ; Bind 6.

Bibtex

@article{98c6c9770c01414d86165c451663edb0,
title = "Persistence and progression of staphylococcal infection in the presence of public goods",
abstract = "Staphylococcus aureus is a prominent etiological agent of suppurative abscesses. In principle, abscess formation and purulent exudate are classical physiological features of healing and tissue repair. However, S. aureus deploys two coagulases that can usurp this classical host response and form distinct abscess lesions. Here, we establish that during coinfection with coagulase producers and non-producers, coagulases are shared public goods that contribute to staphylococcal persistence, abscess formation, and disease progression. Coagulase-negative mutants that do not produce the public goods themselves are able to exploit those cooperatively secreted by producers and thereby thrive during coinfection at the expense of others. This study shows the importance of social interactions among pathogens concerning clinical outcomes.",
author = "Urvish Trivedi and Cody Fell and Madsen, {Jonas S.} and Jake Everett and Mette Burm{\o}lle and Rumbaugh, {Kendra P.} and S{\o}rensen, {S{\o}ren J.}",
year = "2020",
doi = "10.1038/s41522-020-00168-2",
language = "English",
volume = "6",
journal = "n p j Biofilms and Microbomes",
issn = "2055-5008",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Persistence and progression of staphylococcal infection in the presence of public goods

AU - Trivedi, Urvish

AU - Fell, Cody

AU - Madsen, Jonas S.

AU - Everett, Jake

AU - Burmølle, Mette

AU - Rumbaugh, Kendra P.

AU - Sørensen, Søren J.

PY - 2020

Y1 - 2020

N2 - Staphylococcus aureus is a prominent etiological agent of suppurative abscesses. In principle, abscess formation and purulent exudate are classical physiological features of healing and tissue repair. However, S. aureus deploys two coagulases that can usurp this classical host response and form distinct abscess lesions. Here, we establish that during coinfection with coagulase producers and non-producers, coagulases are shared public goods that contribute to staphylococcal persistence, abscess formation, and disease progression. Coagulase-negative mutants that do not produce the public goods themselves are able to exploit those cooperatively secreted by producers and thereby thrive during coinfection at the expense of others. This study shows the importance of social interactions among pathogens concerning clinical outcomes.

AB - Staphylococcus aureus is a prominent etiological agent of suppurative abscesses. In principle, abscess formation and purulent exudate are classical physiological features of healing and tissue repair. However, S. aureus deploys two coagulases that can usurp this classical host response and form distinct abscess lesions. Here, we establish that during coinfection with coagulase producers and non-producers, coagulases are shared public goods that contribute to staphylococcal persistence, abscess formation, and disease progression. Coagulase-negative mutants that do not produce the public goods themselves are able to exploit those cooperatively secreted by producers and thereby thrive during coinfection at the expense of others. This study shows the importance of social interactions among pathogens concerning clinical outcomes.

U2 - 10.1038/s41522-020-00168-2

DO - 10.1038/s41522-020-00168-2

M3 - Journal article

C2 - 33247129

VL - 6

JO - n p j Biofilms and Microbomes

JF - n p j Biofilms and Microbomes

SN - 2055-5008

M1 - 55

ER -

ID: 252304356