Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses

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Standard

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses. / Hadrup, Niels; Knudsen, Kristina Bram; Berthing, Trine; Wolff, Henrik; Bengtson, Stefan; Kofoed, Christian; Espersen, Roall; Højgaard, Casper; Winther, Jakob Rahr; Willemoës, Martin; Wedin, Irene; Nuopponen, Markus; Alenius, Harri; Norppa, Hannu; Wallin, Håkan; Vogel, Ulla.

I: Environmental Toxicology and Pharmacology, Bind 66, 2019, s. 116-125.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hadrup, N, Knudsen, KB, Berthing, T, Wolff, H, Bengtson, S, Kofoed, C, Espersen, R, Højgaard, C, Winther, JR, Willemoës, M, Wedin, I, Nuopponen, M, Alenius, H, Norppa, H, Wallin, H & Vogel, U 2019, 'Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses', Environmental Toxicology and Pharmacology, bind 66, s. 116-125. https://doi.org/10.1016/j.etap.2019.01.003

APA

Hadrup, N., Knudsen, K. B., Berthing, T., Wolff, H., Bengtson, S., Kofoed, C., Espersen, R., Højgaard, C., Winther, J. R., Willemoës, M., Wedin, I., Nuopponen, M., Alenius, H., Norppa, H., Wallin, H., & Vogel, U. (2019). Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses. Environmental Toxicology and Pharmacology, 66, 116-125. https://doi.org/10.1016/j.etap.2019.01.003

Vancouver

Hadrup N, Knudsen KB, Berthing T, Wolff H, Bengtson S, Kofoed C o.a. Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses. Environmental Toxicology and Pharmacology. 2019;66:116-125. https://doi.org/10.1016/j.etap.2019.01.003

Author

Hadrup, Niels ; Knudsen, Kristina Bram ; Berthing, Trine ; Wolff, Henrik ; Bengtson, Stefan ; Kofoed, Christian ; Espersen, Roall ; Højgaard, Casper ; Winther, Jakob Rahr ; Willemoës, Martin ; Wedin, Irene ; Nuopponen, Markus ; Alenius, Harri ; Norppa, Hannu ; Wallin, Håkan ; Vogel, Ulla. / Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses. I: Environmental Toxicology and Pharmacology. 2019 ; Bind 66. s. 116-125.

Bibtex

@article{cd564dc66c3442958f509c2364f32a52,
title = "Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses",
abstract = "We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2–20 μm in length, 2–15 nm in width, 2) AS (−COOH), carboxylated, 0.5–10 μm in length, 4–10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. FINE NFC administration increased neutrophil influx in BAL and induced SAA3 in plasma. AS (−COOH) produced lower neutrophil influx and systemic SAA3 levels than FINE NFC. Results obtained with BIOCID FINE NFC suggested that BIM MC4901 biocide did not explain the lowered response. Increased DNA damage levels were observed across materials, doses and time points. In conclusion, carboxylation of nanofibrillated cellulose was associated with reduced pulmonary and systemic toxicity, suggesting involvement of OH groups in the inflammatory and acute phase responses.",
keywords = "Genotoxicity, Nanocellulose, Nanomaterial, Nanoparticle, Neutrophils, Serum amyloid A",
author = "Niels Hadrup and Knudsen, {Kristina Bram} and Trine Berthing and Henrik Wolff and Stefan Bengtson and Christian Kofoed and Roall Espersen and Casper H{\o}jgaard and Winther, {Jakob Rahr} and Martin Willemo{\"e}s and Irene Wedin and Markus Nuopponen and Harri Alenius and Hannu Norppa and H{\aa}kan Wallin and Ulla Vogel",
year = "2019",
doi = "10.1016/j.etap.2019.01.003",
language = "English",
volume = "66",
pages = "116--125",
journal = "Environmental Toxicology and Pharmacology",
issn = "1382-6689",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses

AU - Hadrup, Niels

AU - Knudsen, Kristina Bram

AU - Berthing, Trine

AU - Wolff, Henrik

AU - Bengtson, Stefan

AU - Kofoed, Christian

AU - Espersen, Roall

AU - Højgaard, Casper

AU - Winther, Jakob Rahr

AU - Willemoës, Martin

AU - Wedin, Irene

AU - Nuopponen, Markus

AU - Alenius, Harri

AU - Norppa, Hannu

AU - Wallin, Håkan

AU - Vogel, Ulla

PY - 2019

Y1 - 2019

N2 - We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2–20 μm in length, 2–15 nm in width, 2) AS (−COOH), carboxylated, 0.5–10 μm in length, 4–10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. FINE NFC administration increased neutrophil influx in BAL and induced SAA3 in plasma. AS (−COOH) produced lower neutrophil influx and systemic SAA3 levels than FINE NFC. Results obtained with BIOCID FINE NFC suggested that BIM MC4901 biocide did not explain the lowered response. Increased DNA damage levels were observed across materials, doses and time points. In conclusion, carboxylation of nanofibrillated cellulose was associated with reduced pulmonary and systemic toxicity, suggesting involvement of OH groups in the inflammatory and acute phase responses.

AB - We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2–20 μm in length, 2–15 nm in width, 2) AS (−COOH), carboxylated, 0.5–10 μm in length, 4–10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. FINE NFC administration increased neutrophil influx in BAL and induced SAA3 in plasma. AS (−COOH) produced lower neutrophil influx and systemic SAA3 levels than FINE NFC. Results obtained with BIOCID FINE NFC suggested that BIM MC4901 biocide did not explain the lowered response. Increased DNA damage levels were observed across materials, doses and time points. In conclusion, carboxylation of nanofibrillated cellulose was associated with reduced pulmonary and systemic toxicity, suggesting involvement of OH groups in the inflammatory and acute phase responses.

KW - Genotoxicity

KW - Nanocellulose

KW - Nanomaterial

KW - Nanoparticle

KW - Neutrophils

KW - Serum amyloid A

U2 - 10.1016/j.etap.2019.01.003

DO - 10.1016/j.etap.2019.01.003

M3 - Journal article

C2 - 30665014

AN - SCOPUS:85060087147

VL - 66

SP - 116

EP - 125

JO - Environmental Toxicology and Pharmacology

JF - Environmental Toxicology and Pharmacology

SN - 1382-6689

ER -

ID: 212858405