Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death. / Aladdin, H; Ullum, H; Lepri, A Cozzi; Leffers, H; Katzenstein, T; Gerstoft, J; Gjedde, S B; Phillips, A N; Skinhøj, P; Pedersen, Bente Klarlund.

In: Scandinavian Journal of Immunology, Vol. 50, No. 2, 08.1999, p. 223-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Aladdin, H, Ullum, H, Lepri, AC, Leffers, H, Katzenstein, T, Gerstoft, J, Gjedde, SB, Phillips, AN, Skinhøj, P & Pedersen, BK 1999, 'Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death', Scandinavian Journal of Immunology, vol. 50, no. 2, pp. 223-7.

APA

Aladdin, H., Ullum, H., Lepri, A. C., Leffers, H., Katzenstein, T., Gerstoft, J., Gjedde, S. B., Phillips, A. N., Skinhøj, P., & Pedersen, B. K. (1999). Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death. Scandinavian Journal of Immunology, 50(2), 223-7.

Vancouver

Aladdin H, Ullum H, Lepri AC, Leffers H, Katzenstein T, Gerstoft J et al. Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death. Scandinavian Journal of Immunology. 1999 Aug;50(2):223-7.

Author

Aladdin, H ; Ullum, H ; Lepri, A Cozzi ; Leffers, H ; Katzenstein, T ; Gerstoft, J ; Gjedde, S B ; Phillips, A N ; Skinhøj, P ; Pedersen, Bente Klarlund. / Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death. In: Scandinavian Journal of Immunology. 1999 ; Vol. 50, No. 2. pp. 223-7.

Bibtex

@article{a2355215554a418c8603f4b22bd14be5,
title = "Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death",
abstract = "The ability of cytotoxic T lymphocytes (CTL) to control and influence the outcome of human immunodeficiency virus (HIV) infection is not fully understood. The association between HIV-CTL activity and disease progression was evaluated prospectively in 36 HIV-1-infected individuals with a median follow-up of 3.0 years. HIV-CTL activity was measured in a 4 h Cr* release assay using autologous target cells expressing HIV-1 BRU isolate gene products (gp-120, gag, pol, nef) and a bulk culture of autologous effector cells. The CD4 count was measured at enrolment and plasma HIV RNA was measured retrospectively. The present study failed to support the hypothesis that HIV-CTL activity, as measured using the present method, is important in reducing the risk of death in HIV-infected individuals. However, using other approaches and methods could possibly yield other conclusions, and further prospective studies are needed to examine the relationship between CTL and disease progression.",
keywords = "Adult, CD4 Lymphocyte Count, Cells, Cultured, Disease Progression, Female, Follow-Up Studies, Gene Products, gag, Gene Products, nef, Gene Products, pol, HIV Antigens, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Male, Middle Aged, RNA, Viral, Retrospective Studies, Risk Factors, T-Lymphocytes, Cytotoxic, nef Gene Products, Human Immunodeficiency Virus, Journal Article, Research Support, Non-U.S. Gov't",
author = "H Aladdin and H Ullum and Lepri, {A Cozzi} and H Leffers and T Katzenstein and J Gerstoft and Gjedde, {S B} and Phillips, {A N} and P Skinh{\o}j and Pedersen, {Bente Klarlund}",
year = "1999",
month = aug,
language = "English",
volume = "50",
pages = "223--7",
journal = "Scandinavian Journal of Immunology, Supplement",
issn = "0301-6323",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Bulk culture levels of specific cytotoxic T-cell activity against HIV-1 proteins are not associated with risk of death

AU - Aladdin, H

AU - Ullum, H

AU - Lepri, A Cozzi

AU - Leffers, H

AU - Katzenstein, T

AU - Gerstoft, J

AU - Gjedde, S B

AU - Phillips, A N

AU - Skinhøj, P

AU - Pedersen, Bente Klarlund

PY - 1999/8

Y1 - 1999/8

N2 - The ability of cytotoxic T lymphocytes (CTL) to control and influence the outcome of human immunodeficiency virus (HIV) infection is not fully understood. The association between HIV-CTL activity and disease progression was evaluated prospectively in 36 HIV-1-infected individuals with a median follow-up of 3.0 years. HIV-CTL activity was measured in a 4 h Cr* release assay using autologous target cells expressing HIV-1 BRU isolate gene products (gp-120, gag, pol, nef) and a bulk culture of autologous effector cells. The CD4 count was measured at enrolment and plasma HIV RNA was measured retrospectively. The present study failed to support the hypothesis that HIV-CTL activity, as measured using the present method, is important in reducing the risk of death in HIV-infected individuals. However, using other approaches and methods could possibly yield other conclusions, and further prospective studies are needed to examine the relationship between CTL and disease progression.

AB - The ability of cytotoxic T lymphocytes (CTL) to control and influence the outcome of human immunodeficiency virus (HIV) infection is not fully understood. The association between HIV-CTL activity and disease progression was evaluated prospectively in 36 HIV-1-infected individuals with a median follow-up of 3.0 years. HIV-CTL activity was measured in a 4 h Cr* release assay using autologous target cells expressing HIV-1 BRU isolate gene products (gp-120, gag, pol, nef) and a bulk culture of autologous effector cells. The CD4 count was measured at enrolment and plasma HIV RNA was measured retrospectively. The present study failed to support the hypothesis that HIV-CTL activity, as measured using the present method, is important in reducing the risk of death in HIV-infected individuals. However, using other approaches and methods could possibly yield other conclusions, and further prospective studies are needed to examine the relationship between CTL and disease progression.

KW - Adult

KW - CD4 Lymphocyte Count

KW - Cells, Cultured

KW - Disease Progression

KW - Female

KW - Follow-Up Studies

KW - Gene Products, gag

KW - Gene Products, nef

KW - Gene Products, pol

KW - HIV Antigens

KW - HIV Envelope Protein gp120

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Male

KW - Middle Aged

KW - RNA, Viral

KW - Retrospective Studies

KW - Risk Factors

KW - T-Lymphocytes, Cytotoxic

KW - nef Gene Products, Human Immunodeficiency Virus

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 10447929

VL - 50

SP - 223

EP - 227

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

SN - 0301-6323

IS - 2

ER -

ID: 180572145