Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis

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Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis. / Ødum, Niels; Morling, Niels; Friis, J; Heilmann, C; Hyldig-Nielsen, J J; Jakobsen, B K; Pedersen, F K; Platz, P; Ryder, L P; Svejgaard, A.

In: HLA, Vol. 28, No. 4, 1986, p. 245-50.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ødum, N, Morling, N, Friis, J, Heilmann, C, Hyldig-Nielsen, JJ, Jakobsen, BK, Pedersen, FK, Platz, P, Ryder, LP & Svejgaard, A 1986, 'Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis', HLA, vol. 28, no. 4, pp. 245-50.

APA

Ødum, N., Morling, N., Friis, J., Heilmann, C., Hyldig-Nielsen, J. J., Jakobsen, B. K., Pedersen, F. K., Platz, P., Ryder, L. P., & Svejgaard, A. (1986). Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis. HLA, 28(4), 245-50.

Vancouver

Ødum N, Morling N, Friis J, Heilmann C, Hyldig-Nielsen JJ, Jakobsen BK et al. Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis. HLA. 1986;28(4):245-50.

Author

Ødum, Niels ; Morling, Niels ; Friis, J ; Heilmann, C ; Hyldig-Nielsen, J J ; Jakobsen, B K ; Pedersen, F K ; Platz, P ; Ryder, L P ; Svejgaard, A. / Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis. In: HLA. 1986 ; Vol. 28, No. 4. pp. 245-50.

Bibtex

@article{b87b2e40fda311ddb219000ea68e967b,
title = "Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis",
abstract = "Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.",
author = "Niels {\O}dum and Niels Morling and J Friis and C Heilmann and Hyldig-Nielsen, {J J} and Jakobsen, {B K} and Pedersen, {F K} and P Platz and Ryder, {L P} and A Svejgaard",
note = "Keywords: Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Denmark; Female; HLA-D Antigens; HLA-DP Antigens; HLA-DR Antigens; HLA-DR5 Antigen; Histocompatibility Antigens Class II; Humans; Infant; Male",
year = "1986",
language = "English",
volume = "28",
pages = "245--50",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley",
number = "4",

}

RIS

TY - JOUR

T1 - Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis

AU - Ødum, Niels

AU - Morling, Niels

AU - Friis, J

AU - Heilmann, C

AU - Hyldig-Nielsen, J J

AU - Jakobsen, B K

AU - Pedersen, F K

AU - Platz, P

AU - Ryder, L P

AU - Svejgaard, A

N1 - Keywords: Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Denmark; Female; HLA-D Antigens; HLA-DP Antigens; HLA-DR Antigens; HLA-DR5 Antigen; Histocompatibility Antigens Class II; Humans; Infant; Male

PY - 1986

Y1 - 1986

N2 - Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.

AB - Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.

M3 - Journal article

C2 - 3492783

VL - 28

SP - 245

EP - 250

JO - HLA

JF - HLA

SN - 2059-2302

IS - 4

ER -

ID: 10638392