Membrane potential plays a dual role for chloride transport across toad skin

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Standard

Membrane potential plays a dual role for chloride transport across toad skin. / Larsen, Erik Hviid; Rasmussen, B E.

In: BBA General Subjects, Vol. 728, No. 3, 09.03.1983, p. 455-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Larsen, EH & Rasmussen, BE 1983, 'Membrane potential plays a dual role for chloride transport across toad skin', BBA General Subjects, vol. 728, no. 3, pp. 455-9.

APA

Larsen, E. H., & Rasmussen, B. E. (1983). Membrane potential plays a dual role for chloride transport across toad skin. BBA General Subjects, 728(3), 455-9.

Vancouver

Larsen EH, Rasmussen BE. Membrane potential plays a dual role for chloride transport across toad skin. BBA General Subjects. 1983 Mar 9;728(3):455-9.

Author

Larsen, Erik Hviid ; Rasmussen, B E. / Membrane potential plays a dual role for chloride transport across toad skin. In: BBA General Subjects. 1983 ; Vol. 728, No. 3. pp. 455-9.

Bibtex

@article{a1f6f9eb0575406c877bca8ebce19fc2,
title = "Membrane potential plays a dual role for chloride transport across toad skin",
abstract = "The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.",
keywords = "Animals, Biological Transport, Active, Bufo bufo, Cell Membrane, Chlorides, Computers, Epithelium, Kinetics, Membrane Potentials, Skin Physiological Phenomena",
author = "Larsen, {Erik Hviid} and Rasmussen, {B E}",
year = "1983",
month = mar,
day = "9",
language = "English",
volume = "728",
pages = "455--9",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Membrane potential plays a dual role for chloride transport across toad skin

AU - Larsen, Erik Hviid

AU - Rasmussen, B E

PY - 1983/3/9

Y1 - 1983/3/9

N2 - The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.

AB - The Cl- -current through toad skin epithelium depends on the potential in a way consistent with a potential-controlled Cl- permeability. Computer analysis of the Koefoed-Johnsen Ussing two-membrane model provided with constant membrane permeabilities indicates that the voltage- and time-dependent currents are not caused by a trivial Goldmand-type rectification and ion redistributions following transepithelial potential pertubations. Extended with a dynamic Cl- permeability in the apical membrane according to a Hodgkin-Huxley kinetic scheme, the model predicts voltage clamp data which closely resemble experimental observations. This extension of the classic frog skin model implies that the Cl- permeability is activated by a voltage change caused by the inward Na+ current through the apical membrane.

KW - Animals

KW - Biological Transport, Active

KW - Bufo bufo

KW - Cell Membrane

KW - Chlorides

KW - Computers

KW - Epithelium

KW - Kinetics

KW - Membrane Potentials

KW - Skin Physiological Phenomena

M3 - Journal article

C2 - 6402013

VL - 728

SP - 455

EP - 459

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 3

ER -

ID: 103932136