An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer
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An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer. / Madsen, Jonas Stenløkke; Hylling, Ole; Jacquiod, Samuel Jehan Auguste; Pécastaings, Sophia; Hansen, Lars H.; Riber, Leise; Vestergaard, Gisle Alberg; Sørensen, Søren Johannes.
In: ISME Journal, Vol. 12, No. 9, 2018, p. 2330-2334.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer
AU - Madsen, Jonas Stenløkke
AU - Hylling, Ole
AU - Jacquiod, Samuel Jehan Auguste
AU - Pécastaings, Sophia
AU - Hansen, Lars H.
AU - Riber, Leise
AU - Vestergaard, Gisle Alberg
AU - Sørensen, Søren Johannes
PY - 2018
Y1 - 2018
N2 - The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.
AB - The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.
U2 - 10.1038/s41396-018-0183-0
DO - 10.1038/s41396-018-0183-0
M3 - Journal article
C2 - 29899518
AN - SCOPUS:85048481780
VL - 12
SP - 2330
EP - 2334
JO - I S M E Journal
JF - I S M E Journal
SN - 1751-7362
IS - 9
ER -
ID: 199418167