Welcome to the Protein Design and Enzymology (PDE) group website

The Protein Design and Enzymology Group (PDE) is part of the Section for Biomolecular Sciences and focuses on understanding how the primary protein structure (the sequence of aminoacid residues) relates to the 3-D structure and function. The overriding themes in our research portfolio are:

  • Protein Design
  • Protein Dynamics
  • Protein Evolution
  • Protein Function


Jakob R. Winther Jakob R. Winther, Professor
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My scientific work is focused on basic aspects of protein chemistry and using molecular biology and molecular genetics to understand structure-function relationships in proteins. The main areas of experience include disulfide bond formation and thiol-disulfide redox reactions, in particular in a chemical/biophysical setting with a strong focus on in vitro characterization.

Kresten Lindorff-Larsen Kresten Lindorff-Larsen, Professor
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The primary tools used in our research are computational methods that we use to study the structure and dynamics of proteins. A particular focus is methods that combine experimental data from NMR spectroscopy with molecular simulations. In one set of studies we combine experiments and simulations to provide a detailed structural interpretation of the experimental data. In another methods to predict what mutations are likely to occur and give rise to drug resistance and what possible mutations giving rise to drug resistance would actually render the enzyme inactive.

Martin Willemoës Martin Willemoës, Associate Professor
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Our work includes elucidating the mechanism of catalysis and regulation for enzymes involved in complex polysaccharide degradation (amylase, mutanase and alpha-mannosidase), for proteases (HIV protease), antibiotic resistance conferring enzymes like beta-lactamase and small molecule converting enzymes mainly from nucleotide metabolism.






Protein Design and Enzymology Group

Section for Biomolecular Sciences
Ole Maaløes Vej 5
DK-2200 Copenhagen N

Prof. Jakob Rahr Winther
Prof. Kresten Lindorff-Larsen
Assoc. Prof. Martin Willemoës

Recent publications