SBiNLab: Structural Biology and NMR Laboratory

The research and teaching programs of the laboratory are focussed on the structural biology of proteins. Structural Biology of proteins is a discipline of science aiming towards understanding the correlations between molecular structure and function of proteins, which are the vital engines of the biological cell factory.

A wide selection of techniques are implemented at the laboratory including NMR spectroscopy, optical spectroscopy, protein engineering, bioinformatics and molecular biology.

 


Birthe B. Kragelund Birthe B. Kragelund, Professor
KU profile page | Personal web site
By application of NMR spectroscopy, x-ray crystallography, protein engineering and biophysical techniques we seek to map mechanisms of interactions involved in i.e. receptor activation, cell division, signal transduction, immune activation and protein degradation.

Kaare Teilum Kaare Teilum, Associate Professor
KU profile page | Personal web site
Slow conformational changes are of key importance to enzyme function. We use NMR spectroscopy, X-ray diffraction and computational methods to characterize, interpret and rationalize the effects of point mutations on the flexibility, stability and catalysis of enzymes in general.

Kresten Lindorff-Larsen Kresten Lindorff-Larsen, Professor
KU profile page | Personal web site
The primary tools used in our research are computational methods that we use to study the structure and dynamics of proteins. A particular focus is methods that combine experimental data from NMR spectroscopy with molecular simulations. In one set of studies we combine experiments and simulations to provide a detailed structural interpretation of the experimental data. In another methods to predict what mutations are likely to occur and give rise to drug resistance and what possible mutations giving rise to drug resistance would actually render the enzyme inactive.

 

 

 

 

 

 

As part of the research in SBiNLab a number of small applications have been developed. Please find the programs in the list below (click on the titles to access the scripts).

Random coil chemical shifts for intrinsically disordered proteins I

The script automatically calculates the sequence-corrected random coil chemical shifts of a protein, while taking the effects of pH and temperature into consideration. 

Random coil chemical shifts for intrinsically disordered proteins II

This script will calculate the chemical shifts for any protein sequence also including phosphorylations.

IDDomainSpotter

IDDomainSpotter is a sequence-based approach to assess and visualize domain organisation in long intrinsically disordered proteins based on compositional biases.

PYDA

PYDA is a web-based Dashboard tool to easily visualise and fit experimental data from protein purification and spectroscopy. PYDA was developed for the research integrated course “Protein research Lab - Intrinsically Disordered Proteins.

 

 

 

 

We are always happy to receive applications from potential postdocs, PhD, Masters, and Bachelor students, and we welcome applications from both Denmark and abroad. If you are interested in joining the lab or just want to know more about our work, find the relevant scientific staff member and contact us by phone or email – or stop by one of the labs in the Biocenter (see map here).

See currently open positions here.

Postdoc positions

Open positions are advertised broadly in the relevant media.

In addition, chances of obtaining postdoc grants are quite good when applying with Danish and/or international foundations. If you are interested in applying contact the scientific staff member that you would like to work.

PhD projects

The University of Copenhagen offers studentships for students holding a Danish or foreign Masters degree. In addition, possibilities exist to apply for funding from private foundations. Phd students are accepted into the PhD school at the Faculty of Science and become part of the PhD program in Protein Science

Masters and Bachelor students projects

We always offer both Masters and Bachelor projects within our different areas of research. For more information and a list of current projects in the University of Copenhagen project database here.

For all types of positions, please contact the staff to discuss specific projects. 

 

 

Contact

Structural Biology and NMR Laboratory (SBiNLab)

Section for Biomolecular Sciences
Ole Maaløes Vej 5
DK-2200 Copenhagen N

GROUP MEMBERS
Prof. Birthe B. Kragelund
Prof. Kaare Teilum
Prof. Kresten Lindorff-Larsen

Recent publications