Welcome to the Teilum Group
I lead one of four research groups at the Structural Biology and NMR Laboratory (SBiN-Lab). My main focus is on slow protein dynamics and the relationship between enzyme dynamics, function and structure. While I employ a broad spectrum of biophysical techniques, my main specialization is advanced nuclear magnetic resonance spectroscopic techniques. Read more about my research and projects below.
I have significant experience with teaching and student supervision and allways have projects on hand.
A part of my research focuses on slow dynamics in proteins especially in relation to protein misfolding and aggregation. A major unresolved question in these processes is the roles of intermediates and how the structure and thermodynamic properties of these states relate to protein aggregation and fibrillation. These questions are addressed by a number of biophysical techniques including NMR spectroscopy, optical spectroscopy and light scattering techniques as well as protein engeneering. A number of proteins are studied, both proteins related to protein misfolding diseases and proteins that are pure model systems for protein unfolding and fibrillation.
An other line of research aims at understanding enzyme function and characterize the structure and thermodynamics the different states of both enzyme and substrate/product during catalysis. In this work NMR spectroscopy is the major experimental technique.
I am leading a FTP-funded project entitled “Functional Protein Dynamics” with Novozymes A/S and Lindorff-Larsen. I am also involved in the projects “Improving Carbohydrate Binding Properties of Cellulases” together with Novozymes A/S and the project “Understanding Mab stability” with Symphogen A/S. Together with Qunxin She (Biology, UCPH) I am involved in the FTP-funded project “Hot modifications” where a new stabilising post-translational modification in archaea has been discovered. I also collaborate with Jeppe T. Pedersen (Pharmacy, UCPH), Lars Hemmingsen (Chemistry, UCPH) and Peter Thulstrup, (Chemistry, UCPH) on understanding how metal-ions influences protein fibrillation and a project with Ulrik Gether (Neuropharm, UCPH) on “Structure and membrane interactions of the scaffolding protein PICK1”. Finally, I collaborate with Birthe B. Kragelund (Biology, UCPH) on several applications of NMR spectroscopy to address structure/dynamics relationships in proteins.
The Teilum lab is located within SBiNLab on the ground floor, building 3 of the Copenhagen Biocenter (map), close to the centre of Copenhagen. It takes less than 1 hour to travel from Copenhagen's airport to our lab, by train or subway (from the airport to Nørreport station, a 20 minute journey, with trains every 10 minutes) and bus (bus 150S from Nørreport to the stop called "Fredrik Bajers Plads" in the intersection of Tagensvej and Nørre Allé, a 10 minute journey, with buses every 6-8 minutes). From there it is a few minutes walk.
Professor Kaare Teilum
Section for Biomolecular Sciences
The Kaj Ulrik Linderstrøm-Lang Centre for Protein Science
Structural Biology and NMR laboratory
Ole Maaløes Vej 5, room 3-0-38
DK-2200 Copenhagen N
Phone: +45 3532 2029
KU profile: Link