Organ Homeostasis & Physiology Lab


Multicellular organisms have evolved organs and tissues with highly specialized tasks. The function of each organ is modified by local clues and systemic signals derived from other organs to ensure a coordinated response accommodating the physiological needs of the organism.The intestine, which represents one of the largest interfaces with the external environment, plays a key role in relaying environmental inputs to other organs to produce systemic responses. Our team is interested in identifying the intra- and inter-organ couplings contributing to intestinal stem cells biology, gut homeostasis, organism physiology and disease.






























The Drosophila Tumor Necrosis Factor Receptor, Wengen, couples energy expenditure with gut immunity .Rihab Loudhaief, Rouba Jneid, Christian Fokdal Christensen, Duncan Mackay, Ditte S. Andersen, Julien Colombani

Sci Adv. 2023 Jun 9;9(23):eadd4977. doi: 10.1126/sciadv.add4977.


A Dilp8-dependent time window ensures tissue size adjustment in Drosophila.
Blanco-Obregon, D., El Marzkioui, K., Brutscher, F., Kapoor, V., Valzania, L., Andersen, Ditte Skovaa, Colombani, Julien, Narasimha, S., McCusker, D., Léopold, P. & Boulan, L.,        

Nat Commun. 2022 Sep 26;13(1):5629. doi: 10.1038/s41467-022-33387-6.


Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Palmerini, V.; Monzani, S.; Laurichesse, Q.; Loudhaief, R.; Mari, S.; Cecatiello, V.; Olieric, V.; Pasqualato, S.; Colombani, J.;
Andersen DS. & Mapelli, M.
Nat Commun 12, 2070 (2021).


The Drosophila gut: a gatekeeper and coordinator of organism fitness and physiology.
Colombani, J. & Andersen, D.S.
Wiley Interdiscip Rev Dev Biol., Vol. 49, 2020 Mar 16:e378. doi:10.1002/wdev.378.


Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila
Boulan, L.; Andersen, D.S.; Colombani, J.; Boone, E.; Léopold, P.
Developmental Cell, Vol. 49, No. 5, 03.06.2019, p. 811-18.


A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation
de Vreede, G.; Morrison, H.A.; Houser, A.M; Boileau, R.M.; Andersen, D.S.; Colombani, J.; Bilder, D.
Developmental Cell, Vol. 45, No. 5, 04.06.2018, p. 595-605.


The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression
Boone, E.; Colombani, J.; Andersen, D.S.; Léopold, P.
Nature Communications, Vol. 7, 22.11.2016, p. 13505.


The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth
Andersen, D.S.; Colombani, J.; Palmerini, V.; Chakrabandhu, K.; Boone, E.; Röthlisberger, M.; Togweiler, J.; Basler, K.; Mapelli, M.; Hueber, A.O.; Léopold, P.
Nature, Vol. 522, No. 7557, 25.06.2015, p. 482-6.


Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing
Colombani, J.; Andersen, D.S.; Léopold, P.
Science, Vol. 336, No. 6081, 04.05.2012, p. 582-5.











Name Title Phone E-mail
Alphy John Postdoc +4535334576 E-mail
Christian Fokdal Christensen Postdoc +4535325327 E-mail
Ditte Skovaa Andersen Associate Professor +4535326878 E-mail
Duncan John Mackay PhD Fellow +4535321397 E-mail
Elizabeth Catherine Connolly Postdoc +4535334586 E-mail
Julien Colombani Associate Professor +4535320933 E-mail
Rouba Jneid Postdoc +4535334585 E-mail


Organ Homeostasis and Physiology Lab

Section for Cell and Neurobiology
Universitetsparken 15
DK-2100 Copenhagen Ø, Denmark

Associate Professor
Ditte S. Andersen
Associate Professor
Julien Colombani

Funded by

ERC logo

Novo Nordisk Foundation logo


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