Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing. / Colombani, Julien; Andersen, Ditte S; Léopold, Pierre.
In: Science (New York, N.Y.), Vol. 336, No. 6081, 04.05.2012, p. 582-5.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Secreted peptide Dilp8 coordinates Drosophila tissue growth with developmental timing
AU - Colombani, Julien
AU - Andersen, Ditte S
AU - Léopold, Pierre
PY - 2012/5/4
Y1 - 2012/5/4
N2 - Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.
AB - Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.
KW - Animals
KW - Brain/metabolism
KW - Drosophila Proteins/genetics
KW - Drosophila melanogaster/genetics
KW - Ecdysone/biosynthesis
KW - Gene Expression Regulation, Developmental
KW - Genes, Insect
KW - Imaginal Discs/growth & development
KW - Intercellular Signaling Peptides and Proteins/genetics
KW - JNK Mitogen-Activated Protein Kinases/metabolism
KW - Larva/genetics
KW - MAP Kinase Signaling System
KW - Metamorphosis, Biological
KW - RNA Interference
KW - Sequence Deletion
KW - Time Factors
KW - Wings, Animal/growth & development
U2 - 10.1126/science.1216689
DO - 10.1126/science.1216689
M3 - Journal article
C2 - 22556251
VL - 336
SP - 582
EP - 585
JO - Science
JF - Science
SN - 0036-8075
IS - 6081
ER -
ID: 212683105