A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila
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A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila. / Malita, Alina; Kubrak, Olga; Koyama, Takashi; Ahrentløv, Nadja; Texada, Michael J.; Nagy, Stanislav; Halberg, Kenneth V.; Rewitz, Kim.
In: Nature Metabolism, Vol. 4, No. 11, 2022, p. 1532-1550.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila
AU - Malita, Alina
AU - Kubrak, Olga
AU - Koyama, Takashi
AU - Ahrentløv, Nadja
AU - Texada, Michael J.
AU - Nagy, Stanislav
AU - Halberg, Kenneth V.
AU - Rewitz, Kim
N1 - Publisher Copyright: © 2022, The Author(s).
PY - 2022
Y1 - 2022
N2 - Animals must adapt their dietary choices to meet their nutritional needs. How these needs are detected and translated into nutrient-specific appetites that drive food-choice behaviours is poorly understood. Here we show that enteroendocrine cells of the adult female Drosophila midgut sense nutrients and in response release neuropeptide F (NPF), which is an ortholog of mammalian neuropeptide Y-family gut-brain hormones. Gut-derived NPF acts on glucagon-like adipokinetic hormone (AKH) signalling to induce sugar satiety and increase consumption of protein-rich food, and on adipose tissue to promote storage of ingested nutrients. Suppression of NPF-mediated gut signalling leads to overconsumption of dietary sugar while simultaneously decreasing intake of protein-rich yeast. Furthermore, gut-derived NPF has a female-specific function in promoting consumption of protein-containing food in mated females. Together, our findings suggest that gut NPF-to-AKH signalling modulates specific appetites and regulates food choice to ensure homeostatic consumption of nutrients, providing insight into the hormonal mechanisms that underlie nutrient-specific hungers.
AB - Animals must adapt their dietary choices to meet their nutritional needs. How these needs are detected and translated into nutrient-specific appetites that drive food-choice behaviours is poorly understood. Here we show that enteroendocrine cells of the adult female Drosophila midgut sense nutrients and in response release neuropeptide F (NPF), which is an ortholog of mammalian neuropeptide Y-family gut-brain hormones. Gut-derived NPF acts on glucagon-like adipokinetic hormone (AKH) signalling to induce sugar satiety and increase consumption of protein-rich food, and on adipose tissue to promote storage of ingested nutrients. Suppression of NPF-mediated gut signalling leads to overconsumption of dietary sugar while simultaneously decreasing intake of protein-rich yeast. Furthermore, gut-derived NPF has a female-specific function in promoting consumption of protein-containing food in mated females. Together, our findings suggest that gut NPF-to-AKH signalling modulates specific appetites and regulates food choice to ensure homeostatic consumption of nutrients, providing insight into the hormonal mechanisms that underlie nutrient-specific hungers.
U2 - 10.1038/s42255-022-00672-z
DO - 10.1038/s42255-022-00672-z
M3 - Journal article
C2 - 36344765
AN - SCOPUS:85141428212
VL - 4
SP - 1532
EP - 1550
JO - Nature Metabolism
JF - Nature Metabolism
SN - 2522-5812
IS - 11
ER -
ID: 327388275