A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor
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A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor. / Zhao, Chaoyang; Escalante, Lucio Navarro; Chen, Hang; Benatti, Thiago R.; Qu, Jiaxin; Chellapilla, Sanjay; Waterhouse, Robert M.; Wheeler, David; Andersson, Martin N; Bao, Riyue; Batterton, Matthew; Behura, Susanta K; Blankenburg, Kerstin P; Caragea, Doina; Carolan, James C; Coyle, Marcus; El-Bouhssini, Mustapha; Francisco, Liezl; Friedrich, Markus; Gill, Navdeep; Grace, Tony; Grimmelikhuijzen, Cornelis; Han, Yi; Hauser, Frank; Herndon, Nicolae; Holder, Michael; Ioannidis, Panagiotis; Jackson, LaRonda; Javaid, Mehwish; Jhangiani, Shalini N; Johnson, Alisha J; Kalra, Divya; Korchina, Viktoriya; Kovar, Christie L; Lara, Fremiet; Lee, Sandra L; Liu, Xuming; Löfstedt, Christer; Mata, Robert; Mathew, Tittu; Muzny, Donna M; Nagar, Swapnil; Nazareth, Lynne V; Okwuonu, Geoffrey; Ongeri, Fiona; Perales, Lora; Peterson, Brittany F; Pu, Ling-Ling; Robertson, Hugh M; Schemerhorn, Brandon J; Scherer, Steven E; Shreve, Jacob T; Simmons, DeNard; Subramanyam, Subhashree; Thornton, Rebecca L; Xue, Kun; Weissenberger, George M; Williams, Christie E; Worley, Kim C; Zhu, Dianhui; Zhu, Yiming; Harris, Marion O; Shukle, Richard H; Werren, John H; Zdobnov, Evgeny M; Chen, Ming-Shun; Brown, Susan J; Stuart, Jeffery J; Richards, Stephen.
In: Current biology : CB, Vol. 25, No. 5, 2015, p. 613-620.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor
AU - Zhao, Chaoyang
AU - Escalante, Lucio Navarro
AU - Chen, Hang
AU - Benatti, Thiago R.
AU - Qu, Jiaxin
AU - Chellapilla, Sanjay
AU - Waterhouse, Robert M.
AU - Wheeler, David
AU - Andersson, Martin N
AU - Bao, Riyue
AU - Batterton, Matthew
AU - Behura, Susanta K
AU - Blankenburg, Kerstin P
AU - Caragea, Doina
AU - Carolan, James C
AU - Coyle, Marcus
AU - El-Bouhssini, Mustapha
AU - Francisco, Liezl
AU - Friedrich, Markus
AU - Gill, Navdeep
AU - Grace, Tony
AU - Grimmelikhuijzen, Cornelis
AU - Han, Yi
AU - Hauser, Frank
AU - Herndon, Nicolae
AU - Holder, Michael
AU - Ioannidis, Panagiotis
AU - Jackson, LaRonda
AU - Javaid, Mehwish
AU - Jhangiani, Shalini N
AU - Johnson, Alisha J
AU - Kalra, Divya
AU - Korchina, Viktoriya
AU - Kovar, Christie L
AU - Lara, Fremiet
AU - Lee, Sandra L
AU - Liu, Xuming
AU - Löfstedt, Christer
AU - Mata, Robert
AU - Mathew, Tittu
AU - Muzny, Donna M
AU - Nagar, Swapnil
AU - Nazareth, Lynne V
AU - Okwuonu, Geoffrey
AU - Ongeri, Fiona
AU - Perales, Lora
AU - Peterson, Brittany F
AU - Pu, Ling-Ling
AU - Robertson, Hugh M
AU - Schemerhorn, Brandon J
AU - Scherer, Steven E
AU - Shreve, Jacob T
AU - Simmons, DeNard
AU - Subramanyam, Subhashree
AU - Thornton, Rebecca L
AU - Xue, Kun
AU - Weissenberger, George M
AU - Williams, Christie E
AU - Worley, Kim C
AU - Zhu, Dianhui
AU - Zhu, Yiming
AU - Harris, Marion O
AU - Shukle, Richard H
AU - Werren, John H
AU - Zdobnov, Evgeny M
AU - Chen, Ming-Shun
AU - Brown, Susan J
AU - Stuart, Jeffery J
AU - Richards, Stephen
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mechanisms that these arthropods use to induce plant galls are poorly understood. We sequenced the genome of the Hessian fly (Mayetiola destructor; Diptera: Cecidomyiidae), a plant parasitic gall midge and a pest of wheat (Triticum spp.), with the aim of identifying genic modifications that contribute to its plant-parasitic lifestyle. Among several adaptive modifications, we discovered an expansive reservoir of potential effector proteins. Nearly 5% of the 20,163 predicted gene models matched putative effector gene transcripts present in the M. destructor larval salivary gland. Another 466 putative effectors were discovered among the genes that have no sequence similarities in other organisms. The largest known arthropod gene family (family SSGP-71) was also discovered within the effector reservoir. SSGP-71 proteins lack sequence homologies to other proteins, but their structures resemble both ubiquitin E3 ligases in plants and E3-ligase-mimicking effectors in plant pathogenic bacteria. SSGP-71 proteins and wheat Skp proteins interact in vivo. Mutations in different SSGP-71 genes avoid the effector-triggered immunity that is directed by the wheat resistance genes H6 and H9. Results point to effectors as the agents responsible for arthropod-induced plant gall formation.
AB - Gall-forming arthropods are highly specialized herbivores that, in combination with their hosts, produce extended phenotypes with unique morphologies [1]. Many are economically important, and others have improved our understanding of ecology and adaptive radiation [2]. However, the mechanisms that these arthropods use to induce plant galls are poorly understood. We sequenced the genome of the Hessian fly (Mayetiola destructor; Diptera: Cecidomyiidae), a plant parasitic gall midge and a pest of wheat (Triticum spp.), with the aim of identifying genic modifications that contribute to its plant-parasitic lifestyle. Among several adaptive modifications, we discovered an expansive reservoir of potential effector proteins. Nearly 5% of the 20,163 predicted gene models matched putative effector gene transcripts present in the M. destructor larval salivary gland. Another 466 putative effectors were discovered among the genes that have no sequence similarities in other organisms. The largest known arthropod gene family (family SSGP-71) was also discovered within the effector reservoir. SSGP-71 proteins lack sequence homologies to other proteins, but their structures resemble both ubiquitin E3 ligases in plants and E3-ligase-mimicking effectors in plant pathogenic bacteria. SSGP-71 proteins and wheat Skp proteins interact in vivo. Mutations in different SSGP-71 genes avoid the effector-triggered immunity that is directed by the wheat resistance genes H6 and H9. Results point to effectors as the agents responsible for arthropod-induced plant gall formation.
U2 - 10.1016/j.cub.2014.12.057
DO - 10.1016/j.cub.2014.12.057
M3 - Journal article
C2 - 25660540
VL - 25
SP - 613
EP - 620
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 5
ER -
ID: 131243816