Drosophila as a Model for Neuroendocrine Control of Renal Homeostasis
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Drosophila as a Model for Neuroendocrine Control of Renal Homeostasis. / Dow, Julian A. T.; Halberg, Kenneth Veland; Terhzaz, Selim; Davies, Shireen A.
Model Animals in Endocrinology: From Worms to Mouse to Man. ed. / Mike Ludwig; Gil Levkowitz. Newark : Wiley, 2018.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Drosophila as a Model for Neuroendocrine Control of Renal Homeostasis
AU - Dow, Julian A. T.
AU - Halberg, Kenneth Veland
AU - Terhzaz, Selim
AU - Davies, Shireen A.
PY - 2018
Y1 - 2018
N2 - Endocrinology is an intrinsically integrative discipline, and is well suited to study in organisms in which genetic intervention is possible; indeed, such integrative physiology is actually a subset of functional genomics. Drosophila, with its powerful genetic technologies and accessible renal system, makes an ideal organism for studies both of fundamental and applied biology, as well as a model with predictive value for the vast Class of Insects. This review illustrates the application of molecular genetic and transgenic technologies available for work in Drosophila to the study of homeostasis by the renal (Malpighian) tubules. This has furthered our understanding of cell-specific signal transduction mechanisms and transport processes linked to epithelial renal function, which is under complex neuroendocrine control. The insights gained in Drosophila have proved applicable and relevant to other insects, and perhaps beyond.
AB - Endocrinology is an intrinsically integrative discipline, and is well suited to study in organisms in which genetic intervention is possible; indeed, such integrative physiology is actually a subset of functional genomics. Drosophila, with its powerful genetic technologies and accessible renal system, makes an ideal organism for studies both of fundamental and applied biology, as well as a model with predictive value for the vast Class of Insects. This review illustrates the application of molecular genetic and transgenic technologies available for work in Drosophila to the study of homeostasis by the renal (Malpighian) tubules. This has furthered our understanding of cell-specific signal transduction mechanisms and transport processes linked to epithelial renal function, which is under complex neuroendocrine control. The insights gained in Drosophila have proved applicable and relevant to other insects, and perhaps beyond.
U2 - 10.1002/9781119391128
DO - 10.1002/9781119391128
M3 - Book chapter
SN - 9781119390947
BT - Model Animals in Endocrinology
A2 - Ludwig, Mike
A2 - Levkowitz, Gil
PB - Wiley
CY - Newark
ER -
ID: 301815984