Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis

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Drosophila TNF/TNFRs : At the crossroad between metabolism, immunity, and tissue homeostasis. / Colombani, Julien; Andersen, Ditte S.

In: FEBS Letters, Vol. 597, No. 19, 2023, p. 2416-2432.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Colombani, J & Andersen, DS 2023, 'Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis', FEBS Letters, vol. 597, no. 19, pp. 2416-2432. https://doi.org/10.1002/1873-3468.14716

APA

Colombani, J., & Andersen, D. S. (2023). Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis. FEBS Letters, 597(19), 2416-2432. https://doi.org/10.1002/1873-3468.14716

Vancouver

Colombani J, Andersen DS. Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis. FEBS Letters. 2023;597(19):2416-2432. https://doi.org/10.1002/1873-3468.14716

Author

Colombani, Julien ; Andersen, Ditte S. / Drosophila TNF/TNFRs : At the crossroad between metabolism, immunity, and tissue homeostasis. In: FEBS Letters. 2023 ; Vol. 597, No. 19. pp. 2416-2432.

Bibtex

@article{dc640445e063411fb22f8ec1198b160e,
title = "Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis",
abstract = "Tumor necrosis factor (TNF)-α is a highly conserved proinflammatory cytokine with important functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the Drosophila TNF-TNF receptor (TNFR) system and a broad genetic toolbox, the fly has played a pivotal role in deciphering the mechanisms underlying TNF-mediated physiological and pathological functions. In this review, we summarize the recent advances in our understanding of how local and systemic sources of Egr/TNF contribute to its antitumor and tumor-promoting properties, and its emerging functions in adaptive growth responses, sleep regulation, and adult tissue homeostasis. The recent annotation of TNF as an adipokine and its indisputable contribution to obesity- and cancer-associated metabolic diseases have provoked a new area of research focusing on its dual function in regulating immunity and energy homeostasis. Here, we discuss the role of TNFR signaling in coupling immune and metabolic processes and how this might be relevant in the adaption of host to environmental stresses, or, in the case of obesity, promote metabolic derangements and disease.",
keywords = "Drosophila, immunity, metabolism, TNF, tumor",
author = "Julien Colombani and Andersen, {Ditte S.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.",
year = "2023",
doi = "10.1002/1873-3468.14716",
language = "English",
volume = "597",
pages = "2416--2432",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "19",

}

RIS

TY - JOUR

T1 - Drosophila TNF/TNFRs

T2 - At the crossroad between metabolism, immunity, and tissue homeostasis

AU - Colombani, Julien

AU - Andersen, Ditte S.

N1 - Publisher Copyright: © 2023 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

PY - 2023

Y1 - 2023

N2 - Tumor necrosis factor (TNF)-α is a highly conserved proinflammatory cytokine with important functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the Drosophila TNF-TNF receptor (TNFR) system and a broad genetic toolbox, the fly has played a pivotal role in deciphering the mechanisms underlying TNF-mediated physiological and pathological functions. In this review, we summarize the recent advances in our understanding of how local and systemic sources of Egr/TNF contribute to its antitumor and tumor-promoting properties, and its emerging functions in adaptive growth responses, sleep regulation, and adult tissue homeostasis. The recent annotation of TNF as an adipokine and its indisputable contribution to obesity- and cancer-associated metabolic diseases have provoked a new area of research focusing on its dual function in regulating immunity and energy homeostasis. Here, we discuss the role of TNFR signaling in coupling immune and metabolic processes and how this might be relevant in the adaption of host to environmental stresses, or, in the case of obesity, promote metabolic derangements and disease.

AB - Tumor necrosis factor (TNF)-α is a highly conserved proinflammatory cytokine with important functions in immunity, tissue repair, and cellular homeostasis. Due to the simplicity of the Drosophila TNF-TNF receptor (TNFR) system and a broad genetic toolbox, the fly has played a pivotal role in deciphering the mechanisms underlying TNF-mediated physiological and pathological functions. In this review, we summarize the recent advances in our understanding of how local and systemic sources of Egr/TNF contribute to its antitumor and tumor-promoting properties, and its emerging functions in adaptive growth responses, sleep regulation, and adult tissue homeostasis. The recent annotation of TNF as an adipokine and its indisputable contribution to obesity- and cancer-associated metabolic diseases have provoked a new area of research focusing on its dual function in regulating immunity and energy homeostasis. Here, we discuss the role of TNFR signaling in coupling immune and metabolic processes and how this might be relevant in the adaption of host to environmental stresses, or, in the case of obesity, promote metabolic derangements and disease.

KW - Drosophila

KW - immunity

KW - metabolism

KW - TNF

KW - tumor

U2 - 10.1002/1873-3468.14716

DO - 10.1002/1873-3468.14716

M3 - Review

C2 - 37567762

AN - SCOPUS:85168875221

VL - 597

SP - 2416

EP - 2432

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 19

ER -

ID: 366645857