Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.
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Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data. / Hauser, Frank; Williamson, Michael; Cazzamali, Giuseppe; Grimmelikhuijzen, Cornelis J P.
In: Briefings in Functional Genomics and Proteomics, Vol. 4, No. 4, 2006, p. 321-30.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.
AU - Hauser, Frank
AU - Williamson, Michael
AU - Cazzamali, Giuseppe
AU - Grimmelikhuijzen, Cornelis J P
N1 - Keywords: Animals; Drosophila Proteins; Drosophila melanogaster; Genome, Insect; Phylogeny; Receptors, G-Protein-Coupled; Receptors, Invertebrate Peptide; Receptors, Neuropeptide; Receptors, Steroid
PY - 2006
Y1 - 2006
N2 - Most neuropeptide and protein hormone receptors belong to the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The first insect genome, that of the fruitfly Drosophila melanogaster, was sequenced in 2000, and about 200 GPCRs have been annnotated in this model insect. About 50 of these receptors were predicted to have neuropeptides or protein hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have been cloned and for many receptors the endogenous ligand has been identified. In this review, we will give an update about the current knowledge of all Drosophila neuropeptide and protein hormone receptors, and discuss their phylogenetic relationships. Udgivelsesdato: 2006-Feb
AB - Most neuropeptide and protein hormone receptors belong to the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The first insect genome, that of the fruitfly Drosophila melanogaster, was sequenced in 2000, and about 200 GPCRs have been annnotated in this model insect. About 50 of these receptors were predicted to have neuropeptides or protein hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have been cloned and for many receptors the endogenous ligand has been identified. In this review, we will give an update about the current knowledge of all Drosophila neuropeptide and protein hormone receptors, and discuss their phylogenetic relationships. Udgivelsesdato: 2006-Feb
U2 - 10.1093/bfgp/eli003
DO - 10.1093/bfgp/eli003
M3 - Journal article
C2 - 17202123
VL - 4
SP - 321
EP - 330
JO - Briefings in Functional Genomics
JF - Briefings in Functional Genomics
SN - 2041-2649
IS - 4
ER -
ID: 3045719