Interactions of virulent and avirulent leptospires with primary cultures of renal epithelial cells.

Research output: Contribution to journalJournal articleResearchpeer-review

  • S A Ballard
  • M Williamson
  • B Adler
  • T Vinh
  • S Faine
A primary culture system for the cells of mouse renal-tubular epithelium was established and used to observe the adhesion of leptospires. Virulent strains of serovars copenhageni and ballum attached themselves to epithelial cells within 3 h of infection whereas an avirulent variant of serovar copenhageni did not adhere to epithelial cells at all within the experimental period of 24 h. The saprophytic Leptospira biflexa serovar patoc became attached non-specifically to inert glass surfaces as well as to the cells. The adhesion of leptospires to epithelial cells was not inhibited by homologous antibody.
Udgivelsesdato: 1986-Feb
Original languageEnglish
JournalJournal of Medical Microbiology
Issue number1
Pages (from-to)59-67
Number of pages8
Publication statusPublished - 1986

Bibliographical note

Keywords: Adhesiveness; Animals; Antibodies, Bacterial; Antigen-Antibody Reactions; Cells, Cultured; Epithelium; Fluorescent Antibody Technique; Kidney Tubules; Leptospira; Mice; Microscopy, Electron, Scanning

ID: 3046356