TY - JOUR

T1 - The genomes of two key bumblebee species with primitive eusocial organization

AU - Sadd, Ben M.

AU - Barribeau, Seth M.

AU - Bloch, Guy

AU - de Graaf, Dirk C.

AU - Dearden, Peter

AU - Elsik, Christine G.

AU - Gadau, Jürgen

AU - Grimmelikhuijzen, Cornelis

AU - Hasselmann, Martin

AU - Lozier, Jeffrey D

AU - Robertson, Hugh M

AU - Smagghe, Guy

AU - Stolle, Eckart

AU - Van Vaerenbergh, Matthias

AU - Waterhouse, Robert M

AU - Bornberg-Bauer, Erich

AU - Klasberg, Steffen

AU - Bennett, Anna K

AU - Câmara, Francisco

AU - Guigó, Roderic

AU - Hoff, Katharina

AU - Mariotti, Marco

AU - Munoz-Torres, Monica

AU - Murphy, Terence

AU - Santesmasses, Didac

AU - Amdam, Gro V

AU - Beckers, Matthew

AU - Beye, Martin

AU - Biewer, Matthias

AU - Bitondi, Márcia Mg

AU - Blaxter, Mark L

AU - Bourke, Andrew Fg

AU - Brown, Mark Jf

AU - Buechel, Severine D

AU - Cameron, Rossanah

AU - Cappelle, Kaat

AU - Carolan, James C

AU - Christiaens, Olivier

AU - Ciborowski, Kate L

AU - Clarke, David F

AU - Colgan, Thomas J

AU - Collins, David H

AU - Cridge, Andrew G

AU - Dalmay, Tamas

AU - Dreier, Stephanie

AU - du Plessis, Louis

AU - Duncan, Elizabeth

AU - Erler, Silvio

AU - Evans, Jay

AU - Falcon, Tiago

AU - Flores, Kevin

AU - Freitas, Flávia Cp

AU - Fuchikawa, Taro

AU - Gempe, Tanja

AU - Hartfelder, Klaus

AU - Hauser, Frank

AU - Helbing, Sophie

AU - Humann, Fernanda C

AU - Irvine, Frano

AU - Jermiin, Lars S

AU - Johnson, Claire E

AU - Johnson, Reed M

AU - Jones, Andrew K

AU - Kadowaki, Tatsuhiko

AU - Kidner, Jonathan H

AU - Koch, Vasco

AU - Köhler, Arian

AU - Kraus, F Bernhard

AU - Lattorff, H Michael G

AU - Leask, Megan

AU - Lockett, Gabrielle A

AU - Mallon, Eamonn B

AU - Antonio, David S Marco

AU - Marxer, Monika

AU - Meeus, Ivan

AU - Moritz, Robin Fa

AU - Nair, Ajay

AU - Näpflin, Kathrin

AU - Nissen, Inga

AU - Niu, Jinzhi

AU - Nunes, Francis Mf

AU - Oakeshott, John G

AU - Osborne, Amy

AU - Otte, Marianne

AU - Pinheiro, Daniel G

AU - Rossié, Nina

AU - Rueppell, Olav

AU - Santos, Carolina G

AU - Schmid-Hempel, Regula

AU - Schmitt, Björn D

AU - Schulte, Christina

AU - Simões, Zilá Lp

AU - Soares, Michelle Pm

AU - Swevers, Luc

AU - Winnebeck, Eva C

AU - Wolschin, Florian

AU - Yu, Na

AU - Zdobnov, Evgeny M

AU - Aqrawi, Peshtewani K

AU - Blankenburg, Kerstin P

AU - Coyle, Marcus

AU - Francisco, Liezl

AU - Hernandez, Alvaro G

AU - Holder, Michael

AU - Hudson, Matthew E

AU - Jackson, LaRonda

AU - Jayaseelan, Joy

AU - Joshi, Vandita

AU - Kovar, Christie

AU - Lee, Sandra L

AU - Mata, Robert

AU - Mathew, Tittu

AU - Newsham, Irene F

AU - Ngo, Robin

AU - Okwuonu, Geoffrey

AU - Pham, Christopher

AU - Pu, Ling-Ling

AU - Saada, Nehad

AU - Santibanez, Jireh

AU - Simmons, DeNard

AU - Thornton, Rebecca

AU - Venkat, Aarti

AU - Walden, Kimberly Ko

AU - Wu, Yuan-Qing

AU - Debyser, Griet

AU - Devreese, Bart

AU - Asher, Claire

AU - Blommaert, Julie

AU - Chipman, Ariel D

AU - Chittka, Lars

AU - Fouks, Bertrand

AU - Liu, Jisheng

AU - O'Neill, Meaghan P

AU - Sumner, Seirian

AU - Puiu, Daniela

AU - Qu, Jiaxin

AU - Salzberg, Steven L

AU - Scherer, Steven E

AU - Muzny, Donna M

AU - Richards, Stephen

AU - Robinson, Gene E

AU - Gibbs, Richard A

AU - Schmid-Hempel, Paul

AU - Worley, Kim C

PY - 2015

Y1 - 2015

N2 - BACKGROUND: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats.RESULTS: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits.CONCLUSIONS: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation.

AB - BACKGROUND: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats.RESULTS: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits.CONCLUSIONS: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation.

U2 - 10.1186/s13059-015-0623-3

DO - 10.1186/s13059-015-0623-3

M3 - Journal article

C2 - 25908251

VL - 16

JO - Genome Biology (Online Edition)

JF - Genome Biology (Online Edition)

SN - 1474-7596

M1 - 76

ER -