The P-domain or trefoil motif: a role in renewal and pathology of mucous epithelia?
Research output: Contribution to journal › Review › Research › peer-review
By analogy with epidermal growth factor and EGF-like repeats, the P-domain, or trefoil motif, is a characteristic shuffled module containing six invariant cysteine residues that forms the basic unit for a family of mucin-associated peptides. These P-domain peptides are potential modulators of cell growth and they are also expressed under certain pathological conditions. Furthermore, P-domains have been found as components of extracellular mosaic proteins including certain mucins, where they are thought to play a role either in protein-protein or in lectin-like interactions.
Original language | English |
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Journal | Trends in Biochemical Sciences |
Volume | 18 |
Issue number | 7 |
Pages (from-to) | 239-43 |
Number of pages | 5 |
ISSN | 0968-0004 |
DOIs | |
Publication status | Published - Jul 1993 |
- Amino Acid Sequence, Animals, Crohn Disease/metabolism, Epithelium/metabolism, Growth Substances/biosynthesis, Humans, Molecular Sequence Data, Mucins, Mucous Membrane/metabolism, Muscle Proteins, Neuropeptides, Peptides, Trefoil Factor-2, Trefoil Factor-3
Research areas
ID: 347886032