TY - JOUR

T1 - Managing fuels and fluids

T2 - Network integration of osmoregulatory and metabolic hormonal circuits in the polymodal control of homeostasis in insects

AU - Koyama, Takashi

AU - Rana, Danial Wasim

AU - Halberg, Kenneth Veland

N1 - Publisher Copyright: © 2023 The Authors. BioEssays published by Wiley Periodicals LLC.

PY - 2023

Y1 - 2023

N2 - Osmoregulation in insects is an essential process whereby changes in hemolymph osmotic pressure induce the release of diuretic or antidiuretic hormones to recruit individual osmoregulatory responses in a manner that optimizes overall homeostasis. However, the mechanisms by which different osmoregulatory circuits interact with other homeostatic networks to implement the correct homeostatic program remain largely unexplored. Surprisingly, recent advances in insect genetics have revealed several important metabolic functions are regulated by classic osmoregulatory pathways, suggesting that internal cues related to osmotic and metabolic perturbations are integrated by the same hormonal networks. Here, we review our current knowledge on the network mechanisms that underpin systemic osmoregulation and discuss the remarkable parallels between the hormonal networks that regulate body fluid balance and those involved in energy homeostasis to provide a framework for understanding the polymodal optimization of homeostasis in insects.

AB - Osmoregulation in insects is an essential process whereby changes in hemolymph osmotic pressure induce the release of diuretic or antidiuretic hormones to recruit individual osmoregulatory responses in a manner that optimizes overall homeostasis. However, the mechanisms by which different osmoregulatory circuits interact with other homeostatic networks to implement the correct homeostatic program remain largely unexplored. Surprisingly, recent advances in insect genetics have revealed several important metabolic functions are regulated by classic osmoregulatory pathways, suggesting that internal cues related to osmotic and metabolic perturbations are integrated by the same hormonal networks. Here, we review our current knowledge on the network mechanisms that underpin systemic osmoregulation and discuss the remarkable parallels between the hormonal networks that regulate body fluid balance and those involved in energy homeostasis to provide a framework for understanding the polymodal optimization of homeostasis in insects.

KW - insects

KW - interorgan communication

KW - metabolism

KW - Neuropeptides

KW - osmoregulation

U2 - 10.1002/bies.202300011

DO - 10.1002/bies.202300011

M3 - Journal article

C2 - 37327252

AN - SCOPUS:85162028918

VL - 45

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 9

ER -