International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. / Chen, Xin; Tsvetkov, Andrey S.; Shen, Han-ming; Isidoro, Ciro; Ktistakis, Nicholas T.; Linkermann, Andreas; Koopman, Werner J.h.; Simon, Hans-uwe; Galluzzi, Lorenzo; Luo, Shouqing; Xu, Daqian; Gu, Wei; Peulen, Olivier; Cai, Qian; Rubinsztein, David C.; Chi, Jen-tsan; Zhang, Donna D.; Li, Changfeng; Toyokuni, Shinya; Liu, Jinbao; Roh, Jong-lyel; Dai, Enyong; Juhasz, Gabor; Liu, Wei; Zhang, Jianhua; Yang, Minghua; Liu, Jiao; Zhu, Ling-qiang; Zou, Weiping; Piacentini, Mauro; Ding, Wen-xing; Yue, Zhenyu; Xie, Yangchun; Petersen, Morten; Gewirtz, David A.; Mandell, Michael A.; Chu, Charleen T.; Sinha, Debasish; Eftekharpour, Eftekhar; Zhivotovsky, Boris; Besteiro, Sébastien; Gabrilovich, Dmitry I.; Kim, Do-hyung; Kagan, Valerian E.; Bayir, Hülya; Chen, Guang-chao; Ayton, Scott; Lünemann, Jan D.; Komatsu, Masaaki; Krautwald, Stefan; Loos, Ben; Baehrecke, Eric H.; Wang, Jiayi; Lane, Jon D.; Sadoshima, Junichi; Yang, Wan Seok; Gao, Minghui; Münz, Christian; Thumm, Michael; Kampmann, Martin; Yu, Di; Lipinski, Marta M.; Jones, Jace W.; Jiang, Xuejun; Zeh, Herbert J.; Kang, Rui; Klionsky, Daniel J.; Kroemer, Guido; Tang, Daolin.
In: Autophagy, 2024, p. 1-34.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
AU - Chen, Xin
AU - Tsvetkov, Andrey S.
AU - Shen, Han-ming
AU - Isidoro, Ciro
AU - Ktistakis, Nicholas T.
AU - Linkermann, Andreas
AU - Koopman, Werner J.h.
AU - Simon, Hans-uwe
AU - Galluzzi, Lorenzo
AU - Luo, Shouqing
AU - Xu, Daqian
AU - Gu, Wei
AU - Peulen, Olivier
AU - Cai, Qian
AU - Rubinsztein, David C.
AU - Chi, Jen-tsan
AU - Zhang, Donna D.
AU - Li, Changfeng
AU - Toyokuni, Shinya
AU - Liu, Jinbao
AU - Roh, Jong-lyel
AU - Dai, Enyong
AU - Juhasz, Gabor
AU - Liu, Wei
AU - Zhang, Jianhua
AU - Yang, Minghua
AU - Liu, Jiao
AU - Zhu, Ling-qiang
AU - Zou, Weiping
AU - Piacentini, Mauro
AU - Ding, Wen-xing
AU - Yue, Zhenyu
AU - Xie, Yangchun
AU - Petersen, Morten
AU - Gewirtz, David A.
AU - Mandell, Michael A.
AU - Chu, Charleen T.
AU - Sinha, Debasish
AU - Eftekharpour, Eftekhar
AU - Zhivotovsky, Boris
AU - Besteiro, Sébastien
AU - Gabrilovich, Dmitry I.
AU - Kim, Do-hyung
AU - Kagan, Valerian E.
AU - Bayir, Hülya
AU - Chen, Guang-chao
AU - Ayton, Scott
AU - Lünemann, Jan D.
AU - Komatsu, Masaaki
AU - Krautwald, Stefan
AU - Loos, Ben
AU - Baehrecke, Eric H.
AU - Wang, Jiayi
AU - Lane, Jon D.
AU - Sadoshima, Junichi
AU - Yang, Wan Seok
AU - Gao, Minghui
AU - Münz, Christian
AU - Thumm, Michael
AU - Kampmann, Martin
AU - Yu, Di
AU - Lipinski, Marta M.
AU - Jones, Jace W.
AU - Jiang, Xuejun
AU - Zeh, Herbert J.
AU - Kang, Rui
AU - Klionsky, Daniel J.
AU - Kroemer, Guido
AU - Tang, Daolin
PY - 2024
Y1 - 2024
N2 - Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.
AB - Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.
U2 - 10.1080/15548627.2024.2319901
DO - 10.1080/15548627.2024.2319901
M3 - Journal article
C2 - 38442890
SP - 1
EP - 34
JO - Autophagy
JF - Autophagy
SN - 1554-8627
ER -
ID: 387430673